Background: Thermal burn injuries impair the host defence system. Hence, in the present study, we aimed at investigating the changes in the number and phenotype of peripheral blood lymphocyte populations (T, B, and natural killer cells) and their subpopulations in patients with thermal burns and determining the relationships with different sizes of total body surface area (TBSA). Methods: Blood...

Critical illness is associated with muscle wasting and muscle weakness. Using burn injury as a model of local and systemic inflammatory response, we tested the hypothesis that thermal injury causes apoptosis in muscle. After a 40% body surface area burn to rats, abdominal muscles beneath the burn and limb muscles distant from the burn were examined for apoptosis at varying times after burn. Lad...

BACKGROUND The colonization of burn wounds by Pseudomonas aeruginosa can lead to septic shock, organ injuries, and high mortality rates. We hypothesized that negative pressure wound therapy (NPWT) would decrease invasion and proliferation of P. aeruginosa within the burn wound and reduce mortality. METHODS Thermal injuries were induced in anesthetized mice, and P. aeruginosa was applied to th...

Background: Thermal injury can cause many changes in the skin-local responseand in the body in general –systemic response; the metabolic changes represent an important one among systemic response. Dyslipidemia after burn injury is one of the important alterations that resulted from many factors like hypermetabolic state in burn, release of hormones and inflammatory mediators, the aim of this st...

Wound healing following partial thickness thermal burns is commonly hampered by the risk of hypertrophic scarring. Skin myofibroblast (MF) density is commonly increased in postburn healing. The transition between fibroblast-like cells and α-smooth muscle actin (SMA)+ MF possibly begins with CD14+ monocytes, evolving to CD14+ CD34+ fibrocytes, followed by β-SMA+ protomyofibroblast (PMF) maturati...

45% of all hospitalized burn casualties in Israel are children younger than 16 years old. In various hospitals they make up 30-60% of all burn casualties, depending on the proportion of children in the area of hospital intake, social and economic factors and the type of hospital. Length of hospitalization of children is shorter than that of the general population (7.3 vs 9.0 days). Scalding is ...

A thermal wave skin model incorporating surface heat flux from a skin simulant sensor is developed to characterize the thermal performance of heat resistant fabrics covering the skin simulant sensor. Comparisons of time to 2nd-degree skin burn and temperature elevation of skin beneath a layer of fabric between the Pennes' equation and the newly developed thermal wave skin model are performed in...

BACKGROUND The hands are commonly affected in severe thermal burn injuries. Resulting contractures lead to significant loss of function. Burn contracture release and skin grafting are necessary to restore hand function. We report a case in which surgical reconstruction of a volar hand burn was performed with full-thickness skin grafting. The patient had a 40-year follow-up to assess the functio...

Acute burn injuries are among the most devastating forms of trauma and lead to significant morbidity and mortality. Appropriate fluid resuscitation after severe burn, specifically during the first 48 hours following injury, is considered as the single most important therapeutic intervention in burn treatment. Although many formulas have been developed to estimate the required fluid amount in se...

Hands are the most frequent sites of burn injury, complications after thermal hand injury include and proper management is essential to assure that optimal functional recovery is achieved. Although each hand represents less than 3% of the total body surface area, burns to the hand are considered serious injuries and should be referred to a burn center. The thin, highly mobile dorsal skin, the s...