Pharmacologic manipulation of metal pools in tumor cells is a promising strategy for cancer treatment. Here, we reveal how the iron-binding ligands desferrioxamine (DFO), di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT), and di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC) inhibit constitutive and interleukin 6-induced activation of signal transducer and activator ...

We previously demonstrated that 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone (311) and other aroylhydrazone chelators possess potent antineoplastic activity because of their ability to bind iron (Fe). From these studies, we identified structural components of the hydrazones that provide antineoplastic activity, namely the salicylaldehyde and 2-hydroxy-1-naphthylaldehyde moieties. A rela...

Experimental magnetic studies performed on the [{CuLX}2] system (HL = pyridine-2-carbaldehyde thiosemicarbazone, X Cl−, Br−, I−) point to larger electronegativity in X, lower magnitude of antiferromagnetic interactions. In order confirm this and other trends observed dip into them, computational (X Cl− (1), I− (2)) compounds are here reported. The chemical structural comparisons have been exten...

reaction of readily available 2-formyl -1-methyl-5-nitroimidazole (1) with 4-substituted-2-hydrazinothiazoles (2) afforded 2-formyl-l-methyl-5- nitroimidazole 4-substituted -2- thiazolylhydrazones (3). reaction of thiochromitn-4-one (4) with thiosemicarbazide gave thiochroman-4- one thiosemicarbazone (5). reaction of compound 5 with clc- haloaldehyde or ketones y ielded thiochroman--#-one 4-sub...

SUMMARY 2-F o rmylpy rid i ne thiosemicarbazone (PT), 3-hydroxy-2-formylpyridine thiosemicarbazone (3-HP), and 5-hydroxy-2-formylpyridine thiosemicarbazone (5-HP) are potent inhibitors of the growth of Sarcoma 180 ascites cells. PT is quite toxic to the tumor-bearing host and does not markedly extend the lifespan of mice bearing Sarcoma 180; however, the therapeutic potential of 3-1-IP and 5-HP...

Zinc (II) complex, [Zn(25-MBTSC)2I2] (1), where (25-MBTSC = (E)-2-(2,5-dimethoxybenzaldehyde) thiosemicarbazone, has been synthesized from the reaction of ZnI2 with 25-MBTSC in methanol as solvent at 25 ºC. It was characterized by elemental analysis (CHN) and is confirmed by single-crystal X-ray diffraction analysis. The complex 1 crystallizes in a triclinic system, with space group P-ī, having...