Phthalazine derivatives are biological potential compounds having diverse biological activities. In this review, briefly discuss about the effect of phthalazine derivatives on cardiac and kidney functions. A series of 4-(4-bromophenyl) phthalazine and phthalazinone analogs connected through 2-propanol spacer to N-substituted piperazine residue were tested for their effect on β-adrenergic blocki...

New series of pyrimidine, pyridine and thiophene derivatives were prepared by reaction appropriate 3-oxobutanamides with urea, thiourea, active methylene compounds, arylidines, salicyaldehyde, chalcones, benzoylisothiocyanate aminopyrazoles. The antimicrobial activities also studied have been found that; Compounds 2a, 3a, 3c 9 show activity against some bacterial species, whereas, no was observ...

Condensation of 3-acetyl-8-ethoxycoumarin (3) with thiosemicarbazide gave ethylidenehydrazinecarbothioamide 5, which was transformed into the thiazolidin-4-one derivatives 6,7. Interaction of 3 with DMF/POCl(3) gave b-chloroacroline derivative 8. Treatment of 3 with malononitrile gave benzo[c]chromone and 2-aminobenzonitrile derivatives 9 and 10, respectively with respect to the reaction condit...

The key intermediate in this study is synthesis of pyrimidine-5-sulfonamides 2a,b. Further modification of starting material by treatment with ethanolamine, anthranilic acid and 3-bromopropanoic acid yielded the condensed pyrimidine derivatives incorporating sulfonamide moiety such as: imidazopyrimidine 3a,b, pyrimidoquinazoline 4a,b and pyrimidothiazine derivatives 5a,b, respectively, in good ...

The urgent need of neuraminidase inhibitors (NI) has provided an impetus for understanding the structure requisite at molecular level. Our search for selective inhibitors of neuraminidase has led to the identification of pharmacophoric requirements at various positions around acyl thiourea pharmacophore. The main objective of present study is to develop selective NI, with least toxicity and dru...

stressed the freedom from toxicity and potency of carbimazole as an anti-thyroid drug. Though potent, thiourea derivatives had proved to have a significant toxic risk. For this reason, most recent workers have concentrated on a comparison of carbimazole with thiourea drugs in regard to studies of toxicity. McGavack, et al. (1956), in describing their experiences in forty-one cases with special ...