Thoracic aortic mobile thrombus is a rare and significant source of peripheral, visceral, as well as cerebral emboli. A 51-year-old female with a history of emergency left brachial artery embolectomy 5 months previously was referred to our unit for evaluation of a mobile thrombus in the descending thoracic aorta. We describe the successful primary treatment of a symptomatic mobile thrombus in t...

A retrospective review was performed of the Aortic Institute at Yale-New Haven Hospital between 1990 and 2018. Of 907 patients with descending thoracic/thoracoabdominal aortic sizes, excluding those connective tissue disease, mean diameter 4.1 cm in men (68%) 4.8 women (32%). The median radiologic follow-up ∼3 years each subgroup. growth rate significantly greater (0.25 cm/year) than (0.17 cm/y...

We report three patients with a descending thoracic aortic aneurysm (DTAA) and a separate infra-renal abdominal aortic aneurysm (AAA) who had initial endovascular repair of the DTAA followed by repair of AAA. Endovascular stent repair of DTAA avoids the significant morbidity associated with thoracotomy and open repair. Hence more patients with multilevel aortic aneurysm may be eligible for surg...

BACKGROUND Maintenance of the structure and mechanical properties of the thoracic aorta contributes to aortic function and is dependent on the composition of the extracellular matrix and the cellular content within the aortic wall. Age-related alterations in the aorta include changes in cellular content and composition of the extracellular matrix; however, the precise roles of these age-related...

Aortic aneurysm is one several well-known cardiovascular complications in patients with autosomal dominant polycystic kidney disease (ADPCKD). Commonly affected site of aortic aneurysm and its related dissection in ADPCKD is abdominal aorta. Long standing hypertension, haemodialysis, old age are closely related with discovering of aortic aneurysm and dissection in ADPCKD. However, thoracic aort...

Objective: Two cases in which emergency retrograde stenting were performed for occlusion of the left common carotid artery orifice that occurred during thoracic endovascular aortic repair are reported. Case Presentations: In males in their 70s with thoracic aortic aneurysm, oxygen saturation dropped in the left cerebrum immediately after deployment of the thoracic aortic stent graft under gener...

OBJECTIVES To establish an animal model of proximal descending thoracic aortic aneurysm for the study of branched stent grafts. MATERIALS AND METHODS Eleven mongrel dogs underwent the surgical procedure during which an autologous pericardial patch was sewn onto a longitudinal incision in the anterolateral wall of the thoracic aorta near the left subclavian artery to create an artificial thora...

OBJECTIVES Spinal cord deficits are devastating complications after surgery for thoracic and thoracoabdominal aortic aneurysms. We developed a regional spinal cord cooling system using an epidural catheter containing cold saline within an isolated counter-current lumen to prevent such complications and reviewed the clinical results. METHODS We enrolled 37 patients with thoracic (n = 13) and t...

This study investigated the effects of hypertension on regional aortic biomechanical and structural properties in three rat models of vascular calcification: the hypertensive Lewis polycystic kidney (LPK; n = 13) model of chronic kidney disease, spontaneously hypertensive rats (SHRs; n = 12), and calcification in normotensive Lewis rats induced by vitamin D3 and nicotine (VDN; n = 8). Lewis and...

Thoracic aortic aneurysms have been historically considered to be caused by etiologic factors similar to those implied in abdominal aortic aneurysms. However, during the past decade, there has been increasing evidence that almost 20% of thoracic aortic aneurysms may be associated with a genetic disease, often within a syndromic or familial disorder. Moreover, the presence of congenital anomalie...