نتایج جستجو برای: thr399ile

تعداد نتایج: 111  

2015
Kalthoum Tizaoui Wajih Kaabachi Kamel Hamzaoui Agnès Hamzaoui

PURPOSE Asthma is a complex disease, with contributions from multiple genes, various genetic backgrounds, and environmental factors. Many human epidemiological studies have demonstrated that single nucleotide polymorphisms (SNPs) in Toll-like receptor (TLR) genes are inconsistently associated with asthma risk. Some have demonstrated differences concerning the study design and effect size, and c...

2013
Natalia Castaño-Rodríguez Nadeem O. Kaakoush Khean-Lee Goh Kwong Ming Fock Hazel M. Mitchell

BACKGROUND In addition to Helicobacter pylori infection, host genetic factors contribute to gastric cancer (GC). Recognition of H. pylori is known to involve Toll-like receptors (TLR), which subsequently leads to activation of NF-κB. Thus, the overall aim of this study was to estimate for the first time the pooled effect size of polymorphisms in TLR2, TLR4 and CD14 on GC development through a m...

Journal: :Journal of immunology 2008
Prasad Rallabhandi Agnes Awomoyi Karen E Thomas Armelle Phalipon Yukari Fujimoto Koichi Fukase Shoichi Kusumoto Nilofer Qureshi Marcelo B Sztein Stefanie N Vogel

The lipid A of LPS activates TLR4 through an interaction with myeloid differentiation protein-2 (MD-2) and the degree of lipid A acylation affects TLR4 responsiveness. Two TLR4 single nucleotide polymorphisms (Asp299Gly and Thr399Ile) have been associated with LPS hyporesponsiveness. We hypothesized that the combination of hypoacylation and these single nucleotide polymorphisms would exhibit a ...

2015
Charles S. Berenson Ragina L. Kruzel Catherine T. Wrona Manoj J. Mammen Sanjay Sethi Samithamby Jeyaseelan

BACKGROUND Dysfunctional innate responses of alveolar macrophages to nontypeable Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pneumoniae contribute to morbidity in chronic obstructive pulmonary disease (COPD). Our earlier studies discovered impaired COPD alveolar macrophage responses to Toll-like receptor (TLR) ligands of nontypeable H. influenzae and provide rationale for fu...

تاجیک, نادر, موسوی, طاهره , جعفری, محمد, سالک مقدم, علیرضا, سنکیان, مجتبی, فرنیا, پریسا, نصیری, محمدرضا,

  Background & Aim: Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) are the members of the Toll-like receptor family and play important roles in recognition and subsequent immune response against mycobacteria. Two functional polymorphisms for TLR2 (Arg677Trp, C à T Arg753Gln, G à A) and TLR4 (Asp299Gly, A à G Thr399Ile, C à T) genes have been associated with a negative influence on ...

Journal: :iranian journal of allergy, asthma and immunology 0
homa davoodi golestan university of medical sciences, gorgan, iran seyed reza hashemi faculty of animal sciences, gorgan university of agricultural sciences and natural resources, gorgan, iran heng fong seow department of pathology, immunology unit, universiti putra malaysia, 43400 serdang selangor, malaysia

toll-like receptor 4 (tlr4), considered one of  the most important tlr, recognizes lipopolysaccharide of  gram-negative bacteria. recognition  of  ligands by  tlrs  induces signaling pathways resulting in activation of transcriptional factors such as nf-κb which are involved in  the  expression of  inflammatory cytokines and  chemokines. to  prevent  an inappropriate immune response, a complex ...

2014
Taís Silveira Assmann Natália Emerim Lemos Letícia de Almeida Brondani Rodrigo Carlessi Carmen Maldonado-Bernal Miguel Cruz Luis Henrique Canani

Taís Silveira Assmann1,2, Natália Emerim Lemos1,2, Letícia de Almeida Brondani1,2, Rodrigo Carlessi1,2, Carmen Maldonado-Bernal3,4, Miguel Cruz3,4, Luis Henrique Canani1,2 and Daisy Crispim1,2* 1Endocrine Division, Hospital de Clínicas de Porto Alegre. Porto Alegre, Rio Grande do Sul, Brazil 2Postgraduate Program in Medical Sciences: Endocrinology, Universidade Federal do Rio Grande do Sul. Por...

Journal: :BioTechniques 2001
E Lorenz K L Frees D A Schwartz

Despite significant advances in understanding the molecular basis of sepsis and its associated immunological response, sepsis remains a problem worldwide and is associated with a high mortality. Annually, septic shock, the most severe form of sepsis, causes the death of more than 100 000 people in the USA (3,4). Gram-negative bacteria are the most common pathogens associated with bacterial infe...

Journal: :Folia histochemica et cytobiologica 2008
Dominik Strapagiel Karolina Kasztalska Magdalena Druszczyńska Magdalena Kowalewicz-Kulbat Adriana Vrba Agnieszka Matusiak Magdalena Chmiela Wiesława Rudnicka

Tuberculosis (TB) still remains the leading cause of mortality due to bacterial pathogen. The only currently available vaccine against TB, Bacille Calmette-Guérin (BCG) is at best credited with a 50% overall protective efficacy. Skin testing with purified protein derivative (PPD) from Mycobacterium tuberculosis is the method of detecting BCG-induced cell mediated immunity, in vivo. In the previ...

Journal: :Anesthesiology 2011
Tobias Eckle Holger K Eltzschig

A CUTE myocardial infarction and myocardial ischemia are leading causes of shortand long-term morbidity and mortality in the perioperative period. In part, this relates to the fact that treatment options for a myocardial infarction in surgical patients are extremely limited. For example, anticoagulation or treatment with highly effective inhibitors of platelet aggregation may not be an option d...

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