BACKGROUND The majority of patients diagnosed with thrombotic thrombocytopenic purpura have autoantibodies directed towards the spacer domain of ADAMTS13. DESIGN AND METHODS In this study we explored the epitope specificity and immunoglobulin class and immunoglobulin G subclass distribution of anti-ADAMTS13 antibodies. The epitope specificity of anti-spacer domain antibodies was examined usin...

CONTEXT Acute pancreatitis due to thrombotic thrombocytopenic purpura is a well recognized condition. Here, we are reporting a rare converse phenomenon, in which thrombocytopenic purpura occurred secondary to acute pancreatitis. CASE REPORT A 19-year-old male referred to our intensive care unit with diagnosis of acute pancreatitis with multi-organ dysfunction. He had history of severe abdomin...

Thrombotic thrombocytopenic purpura is a rare but serious condition in childhood. It can be idiopathic or a complication of other diseases or drug therapy. We report on a 12-year-old Chinese girl who presented with fulminant systemic lupus erythematosus with progressive renal failure, pancytopenia, and cerebral dysfunction due to thrombotic thrombocytopenic purpura. The patient also had Pneumoc...

the prevalence of helicobacter pylori infection and the effect of its eradication on platelet count in 95 iranian patients with chronic refractory autoimmune thrombocytopenic purpura (critp) was investigated. 69 of 95 patients were infected with h.pylori (72.6%). h.pylori eradication was obtained in 69 infected critp pa tients who were not in remission and had platelet count below 100×109 at th...

T HE EXACT role of the platelet in blood coagulation is the subject of considerable controversy. Although thrombocytopenic plasma exhibits retarded coagulation, a prolonged clotting time is rare in thrombocytopenic purpura. ‘ This has been explained by the theory that even in severe thrombocytopenia sufficient thromboplastin is elaborated to produce normal coagulation.4 In any event, the hemorr...

Chapin, J., Wekslezr, B., Magro, C. & Laurence, J. (2012) Eculizumab in the treatment of refractory idiopathic thrombotic thrombocytopenic purpura. British Journal of Haematology, 157, 772–774. Furlan, M., Robles, R., Galbusera, M., Remuzzi, G., Kyrle, P.A., Brenner, B., Krause, M., Scharrer, I., Aumann, V., Mittler, U., Solenthaler, M. & Lammle, B. (1998) von Willebrand factor-cleaving proteas...

the course of t he disorder is acute and chronic.the acute form o f the disease occurs most c ommonly in children , but is seen i n adults as well . the chronic recurrent f orm occurs most o f t e n in women between t wenty and forty years of age. we have studied 3000 cases from the patients o f hematological and internal department in imam khornaini medical ~~ntre , uni. of tehr an/ i ran. we ...

RECOMMANDATIONS Recommandations du cnr-mat publiées sous l'égide de la Société de Réanimation de Langue Française et de la Société Française d'Hématologie. ARTICLES EN FRANÇAIS L’activité de télémédecine dans les microangiopathies thrombotiques : un progrès dans les maladies rares nécessitant une prise en charge en urgence [Telemedicine in thrombotic microangiopathies: A way forward in rare dis...

IN SWITZERLAND Gasser et al. (1955) described in detail an acute fatal illness occurring in five children. Four were between 2 months and 14 months whilst the fifth was 7 years old. The four chief clinical findings were acquired haemolytic anaemia, acute renal failure, a haemorrhagic diathesis and cerebral symptoms. They considered that the accompanying thrombocytopenic purpura was similar to t...