Anticoagulant treatment is required for the treatment and prevention of thromboembolic disorders. Vitamin K antagonists are commonly used oral anticoagulants worldwide. Acenocoumarol is mono-coumarin derivative with racemic mixture of R (+) and S (-) enantiomers. Efficacy and safety of acenocoumarol has been evaluated in atrial fibrillation, cardiac valve replacement, after myocardial infarctio...

Heparan sulfate glycosaminoglycans (HSGAGs) are an important subset of complex polysaccharides that represent the third major class of biopolymer, along with polynucleic acids and polypeptides. However, the importance of HSGAGs in biological processes is underappreciated because of a lack of effective molecular tools to correlate specific structures with functions. Only recently have significan...

Splenic infarction is an uncommon cause of acute abdomen4. Causes include hematologic disease (such as leukemia, lymphoma, myelofibrosis, polycythemia vera), thromboembolic disorders, splenic vascular disease, pancreatic disorders, vasculitis, portal hypertension, bacterial endocarditis, sickle cell disease and infiltrative disorders1,3. It is a well-documented complication of lymphoma. However...

Disruptions in the orderly activation and recovery of electrical excitation traveling through the heart and the gastrointestinal (GI) tract can lead to arrhythmogenesis. For example, cardiac arrhythmias predispose to thromboembolic events resulting in cerebrovascular accidents and myocardial infarction, and to sudden cardiac death. By contrast, arrhythmias in the GI tract are usually not life-t...

a drug to a pregnant woman. ' A further reason is undoubtedly the difficulties (often more imagined than real) in performing interdisciplinary research. None the less, progress is being made, and several monographs on the clinical pharmacology ofpregnancy have recently been published.2 This series is aimed at practising clinicians who prescribe drugs for women who are, or who may become, pregna...

The present paper aims to review the main pathophysiological links between red blood cell disorders and cardiovascular diseases, provides a brief description of the latest studies in this area, and considers implications for clinical practice and therapy. Anemia is associated with a special risk in proatherosclerotic conditions and heart disease and became a new therapeutic target. Guidelines m...

the aim of this study was to propose a method for improving the power of recognition and classification of thromboembolic syndrome based on the analysis of ‎ gene expression data using artificial neural networks. the studied method was performed on a dataset which contained data about 117 patients admitted to a hospital in durham in 2009. of all the studied patients, 66 patients were suffering ...

the aim of this study was evaluation of enoxaparin utilization in hospitalized patients who had received enoxaparin either for prophylaxis or for treatment of thromboembolic disorders. a total of 356 patients were included in this retrospective study and were analyzed for enoxaparin utilization in terms of prescription patterns, treatment strategy, dosing regimen, indications/contraindications,...

INTERATRIAL SEPTAL DISORDERS, WHICH INCLUDE: atrial septal defect, patent foramen ovale and atrial septal aneurysm, are frequent congenital anomalies found in adult patients. Early detection of these anomalies is important to prevent their hemodynamic and/or thromboembolic consequences. The aims of this study were: to assess the association between impulse conduction disorders and anomalies of ...

The inherited hemoglobin disorders sickle cell disease and thalassemia are the most common monogenetic disorders worldwide. Pulmonary hypertension is one of the leading causes of morbidity and mortality in adult patients with sickle cell disease and thalassemia, and hemolytic disorders are potentially among the most common causes of pulmonary hypertension. The pathogenesis of pulmonary hyperten...