Objective—Patients with venous thromboembolism (VTE) often require temporary warfarin interruption for an invasive procedure. The incidence of thromboembolism and bleeding related to periprocedural anticoagulation management of such patients is unknown. Methods and Results—In a protocol-driven, inception cohort design study, all VTE patients (n 775) referred for periprocedural anticoagulation m...

OBJECTIVE To evaluate the association between use of hormone replacement therapy and the risk of idiopathic venous thromboembolism. DESIGN Population based case-control study. SETTING Population enrolled in the General Practice Research Database, United Kingdom. SUBJECTS A cohort of 347,253 women aged 50 to 79 without major risk factors for venous thromboembolism was identified. Cases wer...

BACKGROUND Venous thromboembolism has genetic determinants, but population-based data on familial risks are limited. OBJECTIVES To examine the familial risk of venous thromboembolism. METHODS We undertook a nationwide study of a cohort of patients with deep venous thrombosis or pulmonary embolism born after 1952. We used the Danish National Registry of Patients covering all Danish hospitals...

OBJECTIVES To determine optimal perioperative antithrombotic management for patients with cardiac diseases undergoing joint replacement surgeries. DATA SOURCES MEDLINE and PubMed database search up to January 2013. STUDY SELECTION Those dealing with perioperative antithrombotic management of patients undergoing orthopaedic operations, especially joint replacement, and also those undergoing ...

BACKGROUND Venous thromboembolism is a common complication of surgery. Although surveys of physician self-reported practices have suggested near universal support for routine use of measures to prevent venous thromboembolism, medical record auditing has demonstrated underuse. OBJECTIVE To assess physician practices of venous thromboembolism prophylaxis in the community hospital setting. MET...

Venous thromboembolism, which includes deep venous thrombosis and pulmonary embolism, is a potentially preventable condition in children. In adults, pharmacologic prophylaxis has been shown to significantly reduce the incidence of venous thromboembolism in distinct patient cohorts. However, pediatric randomized controlled trials have failed to demonstrate the efficacy of pharmacologic prophylax...

In this week’s issue of The BMJ, Vinogradova and colleagues (doi:10.1136/bmj.h2135) report the results of a large study on the effects of combined oral contraceptives on the risk of venous thromboembolism, conducted in two large United Kingdom databases: the Clinical Practice Research Datalink (CPRD) and QResearch. The authors identified over 10 500 cases of VTE in women aged 15-49 years and ar...

Air travel is implicated as a predisposing factor for thromboembolism, which at times can have catastrophic consequences. We present three cases who developed deep vein thrombosis (DVT) and subsequent pulmonary thromboembolism (PTE) after transatlantic air travel.