The plasminogen activator staphylokinase (SAK) is a promising thrombolytic agent for treatment of myocardial infarction. It can specifically stimulate the thrombolysis of both erythrocyte-rich and platelet-rich clots. However, SAK lacks fibrin-binding and thrombin inhibitor activities, two functions which would supplement and potentially improve its thrombolytic potency. Creating a recombinant ...

D a t a e x t r a c t i o n Data were extracted on patient characteristics, symptom duration, use of stents or glycoprotein IIb/IIIa antagonists, thrombolytic agent used, time to treatment, and results. Outcomes included total mortality, reinfarction, stroke, hemorrhagic stroke, major bleeding, and a combined endpoint of death, reinfarction, and disabling stroke. Short-term (4to 6-wk) and long-...

Stroke is usually treated by systemic thrombolytic therapy if the patient presents within an appropriate time window. There is also widespread interest in the development of thrombolytic agents that can be used in cases of delayed presentation. Current agents that can be used in cases of delayed presentation of nerve damage by thrombus. Current systemic thrombolytic therapy is associated with a...

R eperfusion injury is an issue of concern to every physician treating patients with acute myocardial infarction in the 1990s. For patients without specific contraindictions to therapy presenting for medical care early in the course of myocardial infarction, an attempt at reperfusion of ischemic, but not yet necrotic, myocardium is the current standard of clinical care. Whether a patient is tre...

Plasmin, the enzyme responsible for degradation of fibrin in blood clots and thus thrombolysis, is normally formed when its zymogen plasminogen is activated by cleavage of the Arg561-Val562 bond by specific plasminogen activators. We have altered the activation characteristics of plasminogen by substituting the P3, P2, and P1' cleavage site residues with sequences from thrombin-cleavable protei...

Plasmin is a direct-acting thrombolytic agent with a striking hemostatic safety advantage over plasminogen activators in animal models of thrombolysis and bleeding. In contradistinction to plasminogen activators, which risk bleeding at any effective thrombolytic dose, plasmin is tolerated without bleeding at several-fold higher amounts than those needed for thrombolysis. Plasmin has been safe i...

BACKGROUND AND PURPOSE We compared the activity of a new long-half-life, fibrin-specific tissue-type plasminogen activator (TPA) variant with that of wild-type TPA in rabbit models of embolic stroke and peripheral bleeding. METHODS In the embolic stroke model. TPA-induced clot lysis is followed by continuous monitoring of a radiolabeled clot lodged in the middle cerebral artery. Twenty-four h...

Abstract Background Stroke thombolysis has been a proven effective treatment for acute stroke since 1995. Since then Alteplase the standard thrombolytic agent used in hyperacute patient, dose being decided by body weight (0.9mg/kg). 10% of is given as bolus, and remaining 90% an infusion. As based, more than one vial can be required. Tenecteplase recent agent, 2017 large multi-centre randomised...

BACKGROUND In intra-arterial (IA) thrombolysis trials, higher rates of symptomatic intracerebral haemorrhage (sICH) were found than in trials with intravenous (IV) recombinant tissue plasminogen activator (tPA); this observation could have been due to the inclusion of more severely affected patients in IA thrombolysis trials. In the present study, we investigated the rate of sICH in IA and comb...

We read the article, entitled “Successful treatment of a pulmonary embolism with low-dose prolonged infusion of tissue-type plasminogen activator in a 37-year-old female in the early postoperative period,” by Aykan et al. (1) in Anatolian J Cardiol 2014; 14: 400-2. We believe that it can be a really good idea to administer low-dose thrombolytic agents in pulmonary embolism to minimize possible ...