Endothelial cell membrane-bound thrombomodulin (TM) plays a critical role as a cofactor in the protein C pathway, important in regulating coagulation as well as inflammation. Heterogeneous soluble TM fragments circulate in the plasma and are found at increased levels in various diseases such as cardiovascular disease and diabetes, and in ischemic and/or inflammatory endothelial injuries. The an...

Neurology® 2012;78:1 In this issue of Neurology, Giwa et al.1 report robust expression of thrombomodulin (TM) in small vessel disease, i.e., in small brain arteries or arterioles that exhibit the typical hyalinized thickening characteristic of chronic hypertensive changes. Using immunohistochemistry of postmortem brain tissue, the authors demonstrate extensive presence of TM in these small arte...

OBJECTIVE Statins reduce lipids concentration in blood. The latest investigations show they also improved the function of vascular endothelial cells (ECs). Thrombomodulin (TM) is particularly important marker of ECs activity. We investigated the in vitro effect of lovastatin on the expression level of TM gene. METHODS AND RESULTS ECs were incubated for 24 h in culture medium including lovasta...

To the Editor: CAGC-3* and 5*-TGGACGGAGCCAGGCTCCTG-3*) were used to produce two PCR products with overlapping sequences at the mutagenized end. After the first round of PCR, 1 mL of 1:100 dilution Thrombomodulin is a major component of the protein C anticoagulant pathway. Biochemical detection of thrombomodulin defects of the PCR products were used to amplify, in a second round of PCR, a 153-bp...