manifestations have been previously reported, though not well-documented, and usually with coronary artery aneurysm. Our HHT patient had a well-documented myocardial infarction with normal coronary arteries, as shown by our biology data, ECG, TTE, coronarography and RMI results. The ischaemic myocardial lesions might result from our patient’s inherited thrombophilia: factor V Leiden and MTHFR. ...

the aim of this study was to investigate the possible role of multiple inherited thrombophilic gene variations in women with unexplained spontaneous abortions. for this purpose, the factor v leiden (fvl) (rs6025), prothrombin g20210a (rs1799963), mthfr c677t (rs1801133), pai-1 4g/5g (rs1799889), ace i/d (rs1799752), enos e298d (rs1799983), and apo e e2/e3/e4 (rs429358) polymorphisms were genoty...

Association between thrombophilia and pre-eclampsia is a controversial issue as Several case-control studies found at least 1 thrombophilic defect in 40% to 72% of women with pre-eclampsia compared with 8% to 20% of control women with normal pregnancies(4,5,6). But several other studies found no difference in the prevalence of thrombophilia between women with pre-eclampsia and those with normal...

Although controversial, screening for thrombophilia has become common. Testing for antiphospholipid antibodies is indicated in order to guide treatment decisions if there is clinical suspicion for antiphospholipid syndrome. The utility of identifying other thrombophilias in symptomatic venous thromboembolism (VTE) is questionable, as the risk of recurrence does not appear to be increased by an ...

Inherited and acquired thrombophilia are the main cause of thrombosis in pregnant women. A growing number of reports over the last years have suggested that these disorders are also associated with an increased incidence of vascular pathologies resulting in poor gestational outcome. This review covers recent data concerning thrombophilia and vascular placental pathology, and discusses available...