Malaria is among the oldest of diseases. In one form or another, it has infected and affected our ancestors since long before the origin of the human line. During our recent evolution, its influence has probably been greater than that of any other infectious agent. Here we attempt to trace the forms and impacts of malaria from a distant past through historical times to the present. In the last ...

The Khoisan people from Southern Africa maintained ancient lifestyles as hunter-gatherers or pastoralists up to modern times, though little else is known about their early history. Here we infer early demographic histories of modern humans using whole-genome sequences of five Khoisan individuals and one Bantu speaker. Comparison with a 420 K SNP data set from worldwide individuals demonstrates ...

Motivated by the possibility that the fundamental “constants” of nature could vary with time, this paper considers the long term evolution of white dwarf stars under the combined action of proton decay and variations in the gravitational constant. White dwarfs are thus used as a theoretical laboratory to study the effects of possible time variations, especially their implications for the future...

Processors have undergone a tremendous evolution throughout their history. A key milestone in this evolution was the introduction of the microprocessor, term that refers to a processor that is implemented in a single chip. The first microprocessor was introduced by Intel under the name of Intel 4004 in 1971. It contained about 2,300 transistors, was clocked at 740 KHz and delivered 92,000 instr...

Paleo-parasitology may be developed as a new tool to parasite evolution studies. DNA sequences dated thousand years ago, recovered from archaeological material, means the possibility to study parasite-host relationship coevolution through time. Together with tracing parasite-host dispersion throughout the continents, paleo-parasitology points to the interesting field of evolution at the molecul...