Abstract Thymic carcinoid is an uncommon neoplasm that can present with Cushing syndrome. We report a 39-year old woman with symptoms of Cushing syndrome secondary to thymic carcinoid and synchronous with tuberculous lymphadenitis and pulmonary tuberculosis. 

Myasthenia gravis (MG) is a disorder of the neuromuscular junction that can deteriorate into myasthenic crisis, involving weakness bulbar and respiratory muscles. In this study, we describe clinical manifestations identify risk factors, examine treatments outcomes. All 95 patients with generalized MG treated at our center during last 10 years were included in retrospective study. We collected d...

Abstract Background The importance of thymic CT-grading and presence rebound hyperplasia during COVID-19 infection were only investigated in a few studies. This multivariate study aims to evaluate the relation between thymus following: (1) patients' age, (2) blood lymphocytic count, (3) CT-volumetry diseased lung parenchyma, (4) patient's clinical course prognosis, finally (5) final radiologica...

Retinoic-acid-orphan-receptor-C (RORC) is a master regulator of Th17 cells, which are pathogenic in several autoimmune diseases. Genetic Rorc deficiency in mice, while preventing autoimmunity, causes early lethality due to metastatic thymic T cell lymphomas. We sought to determine whether pharmacological RORC inhibition could be an effective and safe therapy for autoimmune diseases by evaluatin...

Micronodular thymic carcinoma (MNCA) is an extremely rare variant of thymic carcinoma. We described a 67-year-old woman, who was referred to our institution for a mediastinal mass. The magnetic resonance imaging (MRI) scan showed a 5.0 cm × 4.1 cm × 2.2 cm infiltrative mass invading adjacent tissue with central cystic change. Histologically, the neoplasm was composed of epithelial tumor cells a...

The factors involved in thymus regeneration after chemotherapy has not been sufficiently explored. This study was aimed to identify the clinical characteristics and single-nucleotide polymorphisms in the gene (IL7R) encoding IL-7Rα associated with thymus renewal after chemotherapy in Chinese Han individuals with lymphoma. The dynamics of thymic activity in 134 adults with Hodgkin lymphoma (HL) ...

Myasthenia gravis (MG) is an autoimmune disease mainly caused by antiacetylcholine receptor autoantibodies (seropositive (SP) disease) or by Abs against unknown autoantigenic target(s) (seronegative (SN) disease). Thymectomy is usually beneficial although thymic hyperplasia with ectopic germinal centers is mainly observed in SP MG. To understand the role of thymus in the disease process, we com...

OBJECTIVES The aim of this study was to analyze the prevalence and clinical features of myasthenia gravis (MG) patients with and without autoimmune thyroid disease (ATD). MATERIALS AND METHODS Between 1999 and 2009, we reviewed a total of 1482 patients with MG. On the basis of thyroid evaluations, as well as neurological, clinical, and serological findings, the patients were divided into grou...

STUDY OBJECTIVES Personal results and validity of videothoracoscopic (VTS) approach to primary mediastinal diseases are analyzed. DESIGN Retrospective review of personal experience. SETTING Department of Surgery, San Giuseppe Hospital, University of Milano, Italy. PATIENTS From September 1991 to January 1999, of a personal series of 1,653 VTS procedures, 118 regarded primary mediastinal d...

A 152-week-old male Royal College of Surgeons (RCS) rat kept as a non-treated animal in a long-term animal study presented with a soft mass in the anterior mediastinum, which adhered to the pleura of the lung. Histopathologically, the mass mainly consisted of round to short spindle-shaped tumor cells that had infiltrated through the hyperplastic thymic tissue. The tumor cells were arranged in l...