32 patients (19 female. 13 male)• suffering from Graves' disease with exophthalmus and five without exophthalmus were studied for various autoantibodies including anti-thyroglobulin (ATAB). anti-microsomal antibody (AMAB). anti-parietal antibodies (APAB) and also circulating immune complex (CrC). 43 normal subjects were tested concurrently. Immunofluorescent technique was employed for auto...

A synthetic peptide homolog corresponding to the C-terminal 30 amino acids of Clostridium perfringens type A enterotoxin (CPE) was conjugated to a thyroglobulin carrier and used to immunize mice. Conjugate-immunized mice produced antibodies which neutralized native CPE cytotoxicity, at least in part, by blocking enterotoxin binding. This peptide may be useful for the development of a vaccine to...

introduction: auto – immune disorders have been implicated as a cause for chronic uricaria and/ or angioedema and thyroid autoimmunity has been increasingly introduced to be associated with that. this study explores the association of thyroid autoimmunity with chronic urticaria and / or angioedema in isfahani patients. methods: anti – thyroperoxidase (ani – tpo) and anti – thyroglobulin (anti –...

Methods: The authors examined 3712 women randomly selected from the general population. Serum was analysed for thyroid peroxidase antibody (TPO-Ab) and thyroglobulin antibodies (Tg-Ab) using assays based on a RIA technique. Data were analysed in logistic regression models to adjust for possible confounders. Women previously treated for thyroid disease or with a pregnancy within one year prior t...

Carcinoembryonic antigen and antibodies to thyroglobulin and to a microsomal fraction of thyroid were measured. Persons examined were normal volunteers, patients with thyroid cancer, and patients with a history of childhood irradiation to the thymus and/or tonsil who were otherwise normal. Elevated antigen and antibodies were most frequently found in the cancer thyroid group. Thyroid cancer pat...

A great deal of circumstantial evidence has linked iodine with the rising incidence of autoimmune thyroiditis in the United States. In our investigations, we have shown directly that T cells from humans with chronic lymphocytic thyroiditis proliferate in the presence of iodinated but not in the presence of noniodinated human thyroglobulin. Moreover, the proliferative response is restored when t...

Thyroglobulin antibody (TgAb) has been used as a surrogate tumor marker of differentiated thyroid carcinoma (DTC) patients. Preoperative TgAb (PreopTgAb) is thought to affect the prevalence, disease severity, and outcome DTC. The objective present study was retrospectively analyze prevalence PreopTgAb in patients diagnosed with DTC its relation cancer characteristics, staging, outcome. A retros...