BACKGROUND The HIV integrase inhibitor raltegravir (RAL) can exacerbate autoimmune diseases in genetically predisposed mice. To evaluate whether this may occur in clinical practice, we clinically monitored HIV-positive patients treated with RAL and measured a panel of autoantibodies (auto-Abs) during the first year of RAL treatment. METHODS This was a longitudinal study in 109 antiretroviral-...

BACKGROUND The study aimed at evaluating the prevalence of thyroid function abnormalities in patients with alopecia areata (AA) and its association with other autoimmune diseases and various autoimmune antibodies. METHOD We retrospectively analyzed medical records of 123 patients with AA. The main site of involvement, pattern, and extent of alopecia as well as presence of the similar disease ...

The interest in the relationship between thyroid dysfunction and obesity is on the increase. This study compares the triiodothyronine-to-thyroxine (T3/T4) ratio in obese and lean children and adolescents, and correlates thyroid hormones with body mass index (BMI) in obese Nigerian children. It is a retrospective study of records of 76 obese children and adolescents with a BMI of 31.7 ± 0.1 kg/m...

OBJECTIVE To study the relationship between suboptimal maternal thyroid function during gestation and breech presentation at term. DESIGN Prospective follow-up study during three trimesters of gestation. PATIENTS A total of 1058 Dutch Caucasian healthy pregnant women were prospectively followed from 12 weeks gestation until term (>or=37 weeks) delivery. MEASUREMENTS Maternal thyroid param...

BACKGROUND This study aimed to evaluate clinical, laboratory, ultrasound (US) and scintigraphyc parameters in thyroid nodule and to develop an auxiliary model for clinical application in the diagnosis of malignancy. METHODS We assessed 143 patients who were surgically treated at a single center, 65% (93) benign vs. 35% (50) malignant lesions at final histology (1998-2008). The clinical, labor...

Autoimmune thyroid disease (AITD) is a multifactorial disease with a genetic susceptibility and environmental factors. The thyroid stimulating hormone receptor gene (TSHR) which is expressed on the surface of the thyroid epithelial cell is thought to be the main auto-antigen and a significant candidate for genetic susceptibility to AITD. This case-control study aimed at evaluating the associati...

Objective: Alopecia areata (AA); is a sudden onset, non-scaring hair loss. Twenty percent of cases are children.Although it thought to be related genetic predisposition, inflammation, immunological processes or psychological triggers, its pathophysiology still not fully understood. This study was planned investigate the levels serum 25-hydroxy vitamin D, B12, thyroid-stimulating hormone (TSH) a...

surement of both serum thyroid-stimulating hormone (TSH) and free thyroxine along with thyroid peroxidase antibodies after a 2to 3-month interval. We agree that repeating thyroid function tests is important as many patients will normalise their TSH results and should not be treated with levothyroxine. Some will show progression to overt biochemical hypothyroidism where treatment is no doubt war...

background: thyroid carcinoma is the most common malignancy of the endocrine system. papillary thyroid carcinoma (ptc) is the most common type of thyroid cancer, accounting for 70–90% of well-differentiated thyroid malignancies. thyroid papillary microcarcinoma is a subtype of papillary carcinoma that included tumors with less than 10mm diameter. as a result of diagnostic methods improvement, p...