Two regions of human thyrotropin (thyroid-stimulating hormone, TSH) receptor (TSHR) (residues 12-44 and 308-364) were selected on the basis that they exhibit no sequence resemblance to luteinizing hormone/chorionic gonadotropin receptor. Five synthetic overlapping peptides (12-30, 24-44, 308-328, 324-344, and 339-364) were studied for their ability to bind 125I-labeled human TSH (hTSH), its iso...

Autoimmune thyroiditis is one of the most common causes acquired hypothyroidism in children and adolescents. Both genetic susceptibility environmental factors play a role etiopathogenesis. We report two cases autoimmune here with varied presentation. them had different clinical features at On investigation, both elevated thyroid-stimulating hormone (TSH), low T4 anti-Thyroid peroxidase (TPO) an...

Background. A recent study has reported that high circulating 25-hydroxyvitamin D [25(OH)D] is associated with low circulating thyroid-stimulating hormone (TSH) levels, but only in younger individuals. The goal of the present study was to explore the relationship between vitamin D status and circulating TSH levels with thyroid autoimmunity and thyroid hormone levels taken into consideration in ...

A 70-year-old female patient underwent thyroidectomy and thyroablative radioiodine treatment for folliculary thyroid cancer with pulmonary metastases (pT1, NO, M1). For thyroid hormone replacement therapy, serum thyroid-stimulating hormone (TSH) concentrations were aimed to be below the lower limit of quantification of the assay (-0.03 mU/mL) with concentrations of free thyroxine and free triio...

To the Editor: We reported 2 cases of ectopic thyroid gland (ETG) masquerading as pituitary adenoma (PA). The first case was a 15‐year‐old boy with growth, and mental retardation whose height was 121 cm and weight was 44 kg on admission. Bone age development index was 40, while bone age showed 6–10 years old. Magnetic resonance imaging (MRI) revealed pituitary hyperplasia [Figure 1a]. Thyroid u...

Radioiodine (RAI) ablation following thyroidectomy is standard of care treatment for patients with intermediate or high risk differentiated thyroid cancer. Traditionally, this has been achieved by forgoing thyroid hormone replacement postoperatively, allowing endogenous thyroid stimulating hormone (TSH) levels to rise. This rise in TSH provides the stimulus for RAI uptake by the thyroid remnant...

abstract objective: thyroid dysfunction complicates the metabolic derangement observed in diabetes mellitus (dm). it is necessary to recognize and treat it, when present, in order to achieve stability of metabolic control in these patients. the aim of this study was to investigate the effect of dm on thyroid hormone levels and other biochemical variables. materials and methods: to determine the...

Thyroid-stimulating hormone (TSH) levels obtained one month after the cessation of anti-thyroid drug treatment were assessed retrospectively for possible use in predicting outcome in 50 patients with a clinical diagnosis of Graves' disease. Thirty-four patients remained in remission at the end of the follow-up period and 16 patients relapsed. Although a TSH level of < 1.2 mU/1 did not discrimin...

Khosrow Adeli Clinical Biochemistry, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, M5G 1X8 Canada List of abbreviations: CALIPER, Canadian Laboratory Initiative on Pediatric Reference Intervals; RIDL, Reference Intervals and Decision Limits; IFCC, International Federation of Clinical Chemistry and Laboratory Medicine; CLSI, Clinical Laboratory Standards Institute; GGT...

This study was conducted to find normative values for thyroid stimulating hormone (TSH) in 1200 cord blood samples of term babies whose mothers were not on any thyroid medications. TSH was estimated within 24 hrs by enzyme immunoassay. A full thyroid profile, viz, T3, T4, TSH, fT3 and fT4 was done at 7-10 days of age in all babies with cord TSH >20 mIU/L. The mean, median and standard deviation...