The start of data taking at the Large Hadron Collider will herald a new era in data volumes and distributed processing in particle physics. Data volumes of hundreds of Terabytes will be shipped to Tier-2 centres for analysis by the LHC experiments using the Worldwide LHC Computing Grid (WLCG). In many countries Tier-2 centres are distributed between a number of institutes, e.g., the geographica...

Src kinase has long been recognized as a factor in the progression of colorectal cancer and seems to play a specific role in the development of the metastatic phenotype. In spite of numerous studies conducted to elucidate the exact role of Src in cancer progression, downstream targets of Src remain poorly understood. Gene expression profiling has permitted the identification of large sets of ge...

The deployed hierarchy of Tier-1 and Tier-2 data centers, as organized within the context of the Worldwide LHC Computing Grid (WLCG), have without question been exceedingly successful in meeting the large-scale, group-level production and grid-level data analysis requirements of the experiments in the first full year of LHC operations. However, the plethora of derived datasets and formats thus ...

In the transcription system for Intonational Variation (IVTS, derived from IViE), prosodic features are transcribed on (1) the rhythmic tier, (2) the local phonetic tier, (3) the global phonetic tier, and (4) the phonological tier. Each tier offers a range of labels which share a general architecture, but language-specific parameters determine which subset of labels a transcriber can choose fro...

T paper presents a utility function model of donors who need to determine their donation to a charity organization that structures and publishes donations by tiers. By considering the prestige associated with each tier level, our analysis suggests that a tiered scheme generates an incentive for donors to raise their donation to the next tier when the originally intended donation is close to the...

In conventional two-tier client-server databases, clients access and modify shared data resident in a common server. As the number of clients increases, the centralized database server can become a performance bottleneck. In order to overcome this scalability problem, a three-tier client-server configuration has been proposed that features the partitioning of clients into logical clusters. Here...

This article is devoted to an empirical investigation of performance of several new large multi-tier ensembles for the detection of cardiac autonomic neuropathy (CAN) in diabetes patients using subsets of the Ewing features. We used new data collected by the diabetes screening research initiative (DiScRi) project, which is more than ten times larger than the data set originally used by Ewing in...

Hierarchically-organized ensembles of shared memory multiprocessors possess a richer and more complex model of locality than previous generation multicomputers with single processor nodes. These dual-tier computers introduce many new factors into the program-mer's performance model. We present a methodology for implementing block-structured numerical applications on dual-tier computers, and a r...

Two-tier network structure is usually used to lighten the energy consumption in Wireless Multimedia Sensor Networks (WMSNs) for large scale surveillance application. Previous methods for target tracking in two-tier WMSNs mostly focused on reducing energy cost to prolong lifetime of the networks without considering the effect of visual target tracking. This paper presents a collaborative multi-t...

Multi-tier architectures provide a means for building scalable distributed services. Caching is a classical technique for enhancing the performance of systems (e.g. database servers, or web servers). Although caching solutions have been successfully studied for individual tiers of multi-tier systems, if collectively applied, these solutions may violate the coherence of cached data. This paper p...