We propose the term "synthetic tissue biology" to describe the use of engineered tissues to form biological systems with metazoan-like complexity. The increasing maturity of tissue engineering is beginning to render this goal attainable. As in other synthetic biology approaches, the perspective is bottom-up; here, the premise is that complex functional phenotypes (on par with those in whole met...

Systems Engineering (SE) tools and methods developed and used in consulting and IT systems integration business are presented in the paper. Effectively managing the uncertainty and unknowns, clearly translating customers’ needs into requirements and further verifying and validating them, as well as the preliminary estimation and the strong control of the full scope of project work (timeline, re...