Introduction: Clinical conditions affecting soft tissue often present with altered mechanical properties (e.g. tumours, fibrosis and/or malignancy). Hence, the MRI based non-invasive analysis of soft tissue mechanical properties has been the focus of many fields of research. Soft tissue mechanical properties are nonlinear with respect to strain, strain-rate and frequency and, due to strain stif...

The health of physiological tissue is governed by the continuous conversion of mechanical stimulus (stress) to bio-chemical response, a concept known as mechanical homeostasis. If this regulatory imperative becomes flawed, it may be detrimental, and consequently invoke or encourage the progression of various musculoskeletal disorders. This notion is corroborated by the quantification of altered...

The objective of this article is to critically evaluate the methods that are used to assess outcomes of remineralization of dentin. Currently, the most used assessment methods fall either into quantitative analysis of the mineral content of the remineralized structures or dry measurements of their mechanical properties. Properties obtained from the dehydrated organic dentin matrix may not refle...

Skin biothermomechanics is highly interdisciplinary, involving bioheat transfer, burn damage, biomechanics, and physiology. Characterization of the thermomechanical behavior of skin tissue is of great importance and can contribute to a variety of medical applications. However, few quantitative studies have been conducted on the thermally-dependent mechanical properties of skin tissue. The aim o...

There is a critical need for tissue engineered replacements for diseased and degenerated intervertebral discs in order to assuage low back pain while restoring function to the spine. Despite progress by many research groups, it remains a challenge to engineer a replacement tissue that can withstand the complex, demanding loading environment of the spine. Due to the hierarchical organization of ...

non-invasive ultrasound surgeries such as high intensity focused ultrasound have been developed to treat tumors or to stop bleeding. in this technique, incorporation of a suitable imaging modality to monitor and control the treatments is essential so several imaging methods such as x-ray, magnetic resonance imaging and ultrasound imaging have been proposed to monitor the induced thermal lesions...

Identification of the deformation mechanisms and specific components underlying the mechanical function of biological tissues requires mechanical testing at multiple levels within the tissue hierarchical structure. Dichlorotriazinylaminofluorescein (DTAF) is a fluorescent dye that is used to visualize microscale deformations of the extracellular matrix in soft collagenous tissues. However, the ...

The fundamental passive mechanical properties of the bladder need to be known in order to design the most appropriate long-term surgical repair procedures and develop materials for bladder reconstruction. This study has focused on the bladder tissue viscoelastic behavior, providing a comprehensive analysis of the effects of fibers orientation, strain rate and loading history. Whole bladders har...

The nonlinear mechanical behavior of tissues that undergo large deformations, e.g. the breast, is characterized by hyperelastic parameters. These parameters take into account both types of nonlinearities: tissue intrinsic nonlinearity and geometric nonlinearity. Elastography technique capable of tissue hyperelastic parameter reconstruction has important clinical applications such as cancer diag...

While traumatic aortic rupture (TAR) continues to be a major cause of fatality in motor vehicle accidents, its underlying mechanisms at the tissue level are not well understood. During accidents, aorta may undergo high-rate large deformations and therefore, the tissue mechanical properties obtained in the physiological range cannot accurately describe the tissue behavior in such conditions. Ver...