Reconstructive microsurgery is a clinical technique used to transfer large amounts of a patient's tissue from one location used to another in order to restore physical deformities caused by trauma, tumors, or congenital abnormalities. The trend in this field is to transfer tissue using increasingly smaller blood vessels, which decreases problems associated with tissue harvest but increases the ...

Long term responses of the heart to e.g. infarction or surgical intervention are related to response of the tissue to changes in the mechanical environment. The tissue response is likely to involve (local) change of mass. Implementation of the associated inhomogeneous change in volume for a complex geometry is cumbersome. In the present study, we propose a computational framework for finite vol...

Modeling the mechanical response of the brain has become increasingly important over the past decades. Although mechanical stimuli to the brain are small under physiological conditions, mechanics plays a significant role under pathological conditions including brain development, brain injury, and brain surgery. Well calibrated and validated constitutive models for brain tissue are essential to ...

Defined genetic models based on human pluripotent stem cells have opened new avenues for understanding disease mechanisms and drug screening. Many of these models assume cell-autonomous mechanisms of disease but it is possible that disease phenotypes or drug responses will only be evident if all cellular and extracellular components of a tissue are present and functionally mature. To derive opt...

Three-dimensional (3D) in vitro models span the gap between two-dimensional cell cultures and whole-animal systems. By mimicking features of the in vivo environment and taking advantage of the same tools used to study cells in traditional cell culture, 3D models provide unique perspectives on the behavior of stem cells, developing tissues and organs, and tumors. These models may help to acceler...

As a theoretical framework for understanding the self-assembly of living cells into tissues, Steinberg proposed the differential adhesion hypothesis (DAH) according to which a specific cell type possesses a specific adhesion apparatus that combined with cell motility leads to cell assemblies of various cell types in the lowest adhesive energy state. Experimental and theoretical efforts of four ...

In this study, a phenomenological tissue damage model has been developed to describe the fatigue-induced stress softening and permanent set of biological tissues. Since damage evolution is an irreversible dissipative process, following thermodynamic principles, an equivalent strain proportional to the strain energy of the material is employed as the damage criterion. The maximum equivalent stra...

In article number 2008662, Elisa Riedo, Giuseppe Maria de Peppo, and co-workers describe a novel thermochemi cal scanning probe lithography (tSPL)-based platform for the low-cost high throughput fabrication of bone tissue replicas in biocompatible material with nanoscale resolution. The bio-tSPL creates unique opportunities understanding cell-tissue microenvironment interactions applications re...

1 Project Summary The goal of this research is to develop a general-purpose computational scheme for representing the geometry and physics of human-body soft-tissue structures and simulating their displacements and deformations in real-time when external forces are applied by surgical instruments. The ability to realistically model soft tissues on a computer has the potential to radically chang...

OBJECTIVE Little is known about the interaction of tissue conditioners and modeling plastics. This study evaluates the influence of a variety of commercial tissue conditioners on alteration of viscoelastic properties of modeling plastics. MATERIALS AND METHODS In this in vitro study, the dynamic viscoelastic properties of four commercially available tissue conditioners (TC), Visco-gel (VG), G...