Different forms of acute kidney injury (AKI) have been associated with endoplasmic reticulum (ER) stress; these include AKI caused by acetaminophen, antibiotics, cisplatin, and radiocontrast. Tunicamycin (TM) is a nucleoside antibiotic known to induce ER stress and is a commonly used inducer of AKI. 4-phenylbutyrate (4-PBA) is an FDA approved substance used in children who suffer from urea cycl...

Current object-oriented systems ooer among others integration of data and methods that are formulated mostly in a third generation programming language; moreover inheritance of data and methods is typically based on an operational semantics. The object-oriented data model TM, however, contains rich data structuring capabilities, a high-level speciication of methods and constraints, and inherita...

The study of a lot of disciplines (e.g. history, geology, archaeology and politics) is often connected to temporal information. The nature of temporal information can be very complex. To help students to understand and memorise time-related knowledge, visualisation is a common approach. Currently, time intervals are usually visualised as linear segments. But, if a lot of information with a comp...

BACKGROUND In Hong Kong, thalassemia major (TM) patients utilized up to 9.5% of blood supply in 2009. For long-term management of blood supply, we predicted the future blood demand of TM patients for the next 10 years. METHODS AND RESULTS Annual individual transfusion data in 2005-2009 and demographic information of 381 TM patients were obtained from the Hong Kong Red Cross Blood Transfusion ...

Modifications of the widely used K-profile model of the planetary boundary layer (PBL), reported by Troen and Mahrt (TM) in 1986, are proposed and their effects examined by comparison with large eddy simulation (LES) data. The modifications involve three parts. First, the heat flux from the entrainment at the inversion layer is incorporated into the heat and momentum profiles, and it is used to...

Electromigration (EM) and thermomigration (TM) are processes of mass transport which are critical reliability issues for next generation nanoelectronics and power electronics. The purpose of this project is to develop a computational tool for simulating damage mechanics of EM and TM and their interaction. In this paper, a model for EM and TM processes is proposed and has been implemented in a g...

Neurology® 2012;78:1 In this issue of Neurology, Giwa et al.1 report robust expression of thrombomodulin (TM) in small vessel disease, i.e., in small brain arteries or arterioles that exhibit the typical hyalinized thickening characteristic of chronic hypertensive changes. Using immunohistochemistry of postmortem brain tissue, the authors demonstrate extensive presence of TM in these small arte...

We have previously demonstrated that transformation by Fos is critically dependent on an intact DNA-binding domain (bZip) and a functional N-terminal transactivation motif (N-TM). We now show that a novel motif (C-terminal transactivation motif [C-TM]) near the C terminus also plays an important role in both transformation and the activation of AP1-dependent transcription and that the hydrophob...

The Env protein of murine leukemia virus matures by two cleavage events. First, cellular furin separates the receptor binding surface (SU) subunit from the fusion-active transmembrane (TM) subunit and then, in the newly assembled particle, the viral protease removes a 16-residue peptide, the R-peptide from the endodomain of the TM. Both cleavage events are required to prime the Env for receptor...