tolerance development

Chronic use of morphine is accompanied by the development of morphine tolerance, which is one of the major problems associated with opiate treatment. Experimental evidence indicates that melanocortin 4 receptor (MC4R) is involved in development of morphine tolerance. Therefore, we investigated the influence of repeated intrathecal injection of a MC4R antagonist (HS014) on the development of mor...

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Mechanisms of immunological tolerance to the antigens of the central nervous system. Skin-induced tolerance as a new therapeutic concept.

Journal: :Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2011

M Szczepanik

The immune system is designed to recognize and eliminate foreign (non-self) antigens. At the same time, there are mechanisms protecting the organism from development of inappropriate immune responses that are harmful to ones own body (allergy, autoimmunity) and those that help to silence the inflammatory responses and allow their resolution. Tolerance to self-antigens is a result of central tol...

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"effect of apamin on tolerance to cocaine-induced locomotor activity in mice"

Journal: :acta medica iranica 0

h. r. jamshidi m. rezayat m. r. zarrindast

in the present study, the effect of apamin (potassium channel blocker) on tolerance to cocaine-induced locomotor activity in mice has been investigated. locomotor activity was measured by locomotor activity meter, animax, type s (lkb, farrad). intraperitoneal (ip) injection of different doses of cocaine (2.5, 5, 10 and 15 mg/kg) produced dose-dependent locomotor activity in mice.animals were tr...

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