Tooth loss is considered to be a public health problem. Time-series studies that assess the influence of social conditions and access to health services on tooth loss are scarce.This study aimed to examine the time-series of permanent tooth extraction in Brazil between 1998 and 2012 and to compare these series in municipalities with different Human Development Index (HDI) scores and with differ...

Patients with Axenfeld-Rieger Syndrome (ARS) present various dental abnormalities, including hypodontia, and enamel hypoplasia. ARS is genetically associated with mutations in the PITX2 gene, which encodes one of the earliest transcription factors to initiate tooth development. Thus, Pitx2 has long been considered as an upstream regulator of the transcriptional hierarchy in early tooth developm...

RELATED TO DENTAL DEFECTS CAUSING TOOTH LOSS Tooth agenesis is the most prevalent craniofacial congenital malformation in humans. Up to 25% of the population may lose at least one third molar. Agenesis of other permanent teeth, excluding third molars, ranges from 1.6 to 9.6%, depending on the population studied. Primary dentition may also be affected, but with lower prevalence (from 0.5 to 0.9%...

Tooth avulsion represents 0.5-16% of traumatic injuries. Avulsion of a pre-eruptive left permanent maxillary incisor in a 6-year-old boy is presented. The immature tooth was replanted after rinsing with saline following 10 min dry extra-oral time. This case report describes treatment and a 2-year follow-up of the tooth. During the follow-up period, continuation of root development, pulp revascu...

Josh has fractured his tooth and exposed the pulp. Although repairing the injury is the immediate problem, ensuring that the tooth will continue to thrive is the real challenge. Understanding the impact of trauma on the pulp and the importance of pulp vitality to sound tooth development is essential for optimum patient care. Endodontics can offer a unique perspective. Endodontic therapy general...

The development of many organs depends on sequential epithelial-mesenchymal interactions, and the developing tooth germ provides a powerful model for elucidating the nature of these inductive tissue interactions. In Msx1-deficient mice, tooth development arrests at the bud stage when Msx1 is required for the expression of Bmp4 and Fgf3 in the dental mesenchyme (Bei, M. and Maas, R. (1998) Devel...

trauma to primary teeth can lead to devastating sequels in development of permanent successors. the disturbance may range from enamel hypoplasia and/or hypo-calcification to arrest of dental bud development. crown dilaceration of permanent teeth is one of the consequences of trauma to deciduous teeth mainly due to intrusion or avulsion. this report presents a mandibular central incisor with dil...

The tooth is a vertebrate-specific organ that deve]ops through a series of reciprocal interactions between epithelium and mesenchyme. In this process, the neural crest (NC) cells participate in tooth development. NC cells are multipotent cells that are generated from the IHteral ridge of the dorsal neural tube during the early stuges of embryogenesis. NC cells migrate into various tissues, wher...

Mammalian tooth development relies heavily on the reciprocal and sequential interactions between cranial neural crest-derived mesenchymal cells and stomadial epithelium. During mouse tooth development, odontogenic potential, that is, the capability to direct an adjacent tissue to form a tooth, resides in dental epithelium initially, and shifts subsequently to dental mesenchyme. Recent studies h...

Like epithelial organs in general, tooth development involves inductive crosstalk between the epithelium and the mesenchyme. Classically, the inductive potential for tooth formation is considered to reside in the mesenchyme during the visible morphogenesis of teeth, and dental mesenchyme can induce tooth formation even when combined with non-dental epithelium. Here, we have investigated inducti...