نتایج جستجو برای: tor grypus
تعداد نتایج: 8028 فیلتر نتایج به سال:
AV, PG, GF, SB Dept. of Internal Medicine-PTV University of Rome “Tor Vergata”, MB, FA, GN Dept. of Biopathology and Diagnostic Imaging University of Rome “Tor Vergata”, RM, GV Dept. of Urology University of Rome “Tor Vergata”, GC, AF, SB CASPURRome, AD Dept. of Biology University of Rome “Tor Vergata”, GF Santa Lucia Foundation-IRCSS, Rome, SB Bambino Gesù Children's Hospital-IRCSS, Rome-Italy...
The target of rapamycin (TOR) protein is a conserved regulator of ribosome biogenesis, an important process for cell growth and proliferation. However, how TOR is involved remains poorly understood. In this study, we find that rapamycin and nutrient starvation, conditions inhibiting TOR, lead to significant nucleolar size reduction in both yeast and mammalian cells. In yeast, this morphological...
The regulation of ribosome biogenesis in response to environmental conditions is a key aspect of cell growth control. Ribosomal protein (RP) genes are regulated by the nutrient-sensitive, conserved target of rapamycin (TOR) signaling pathway. TOR controls the subcellular localization of protein kinase A (PKA) and the PKA-regulated kinase YAK1. However, the target transcription factor(s) of the ...
In response to starvation, eukaryotic cells recover nutrients through autophagy, a lysosomal-mediated process of cytoplasmic degradation. Autophagy is known to be inhibited by TOR signaling, but the mechanisms of autophagy regulation and its role in TOR-mediated cell growth are unclear. Here, we show that signaling through TOR and its upstream regulators PI3K and Rheb is necessary and sufficien...
let $m$ be a non-zero finitely generated module over a commutative noetherian local ring $(r,mathfrak{m})$ with $dim_r(m)=t$. let $i$ be an ideal of $r$ with $grade(i,m)=c$. in this article we will investigate several natural homomorphisms of local cohomology modules. the main purpose of this article is to investigate when the natural homomorphisms $gamma: tor^{r}_c(k,h^c_i(m))to kotim...
The emergence and spread of Vibrio cholerae O1 El Tor variant strains causing severe diarrhea has been witnessed worldwide in recent years. In the state of Odisha, India, the spread of the V. cholerae O1 El Tor variant strains was studied during outbreaks in 2008 and 2009. Analysis of 194 V. cholerae O1 Ogawa strains revealed that V. cholerae O1 El Tor variant strains are spreading gradually th...
We present PeerFlow, a system to securely load balance client traffic in Tor. Security in Tor requires that no adversary handle too much traffic. However, Tor relays are run by volunteers who cannot be trusted to report the relay bandwidths, which Tor clients use for load balancing. We show that existing methods to determine the bandwidths of Tor relays allow an adversary with little bandwidth ...
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