Intensity-modulated radiation therapy (IMRT) for total body irradiation (TBI) is practiced in several centers using the TomoTherapy System. In this context the planning target volume (PTV) is the entire body including the skin. A safety margin in the air surrounding the body should be added to take into account setup errors. But using inverse planning, over-fluence peak could be generated in th...

Total-body irradiation (TBI) with 0.02-0.25 Gy has been reported to have antitumor effects. In mice, low-dose TBI induces tumor growth delay, antimetastatic effects, suppressive effects on the incidence of spontaneous thymiclymphoma, sensitization of tumor to ionizing radiation, and decrease in TD50 value. In artificial metastasis, 0.20 Gy TBI suppressed lung metastasis when it was conducted be...

The purpose of this study was to retrospectively evaluate the incidence of delayed renal dysfunction after total body irradiation (TBI) in long-term survivors of TBI/hematopoietic stem cell transplantation (HSCT). Between 1989 and 2006, 24 pediatric patients underwent TBI as part of the conditioning regimen for HSCT at Chiba University Hospital. Nine patients who survived for more than 5 years ...

We have constructed a computer controlled translational couch to administer total body irradiation reproducibly and safely. The system has replaced the previous stationary anterior-posterior technique in our institution and 30 plus patients have been treated with it so far. In this technique, patients comfortably lie on a couch in supine and prone positions and are transported slowly through a ...

Separate and combined effects of methotrexate and total body irradiation were studied on normal lungs of mouse. Forty female albino mice weighing 25 to 30 gms were divided into five groups including that of controls. On gross inspection, 70% of lungs of combined therapy group showed signs of congestion, 10% edematous changes and 20% blackish mottling. Microscopic examination revealed marked his...

Acute radiation sickness (ARS) following exposure to ionizing irradiation is characterized by radiation-induced multiorgan dysfunction/failure that refers to progressive dysfunction of two or more organ systems, the etiological agent being radiation damage to cells and tissues over time. Radiation sensitivity data on humans and animals has made it possible to describe the signs associated with ...

Case Report: A 78-year-old male with relapsed Waldenstrom’s macroglobulinemia following therapy with chlorambucil underwent a five-week course of TBI. The total dose delivered was 1.5 Gy, given as 0.15 Gy twice weekly for ten sessions. During the course of therapy his CD4 cells increased from 637 (cells/mm3) to 808 partly through treatment and then declined to 654 at the completion of therapy. ...

By C. C. CONGDON W IDE INTEREST in the experimental treat-meat of tot-al-body irradiation injury by post-irradiation injectioii of living blood-forming cells is evident from the many reports in this field. Discussions among biologists amid medical workers indicate an active interest in the potential applications of this particular radiobiologic research to human disease. The results of an anima...

Exposure to ionizing radiation (IR) and certain chemotherapeutic agents not only causes acute bone marrow (BM) suppression but also leads to long-term residual hematopoietic injury. This latter effect has been attributed to damage to hematopoietic stem cell (HSC) self-renewal. Using a mouse model, we investigated whether IR induces senescence in HSCs, as induction of HSC senescence can lead to ...