A subset S ⊆ V in a graph G = (V,E) is a total [1, 2]-set if, for every vertex v ∈ V , 1 ≤ |N(v) ∩ S| ≤ 2. The minimum cardinality of a total [1, 2]-set of G is called the total [1, 2]-domination number, denoted by γt[1,2](G). We establish two sharp upper bounds on the total [1,2]-domination number of a graph G in terms of its order and minimum degree, and characterize the corresponding extrema...