Riboswitches are natural ligand-sensing RNAs typically that are found in the 5' UTRs of mRNA. Numerous classes of riboswitches have been discovered, enabling mRNA to be regulated by diverse and physiologically important cellular metabolites and small molecules. Here we describe Spinach riboswitches, a new class of genetically encoded metabolite sensor derived from naturally occurring riboswitch...

Thyrotoxic periodic paralysis (TPP) is a life-threatening neuromuscular complication of thyrotoxicosis characterized by muscle weakness and hypokalemia and with an unclear etiopathogenesis. However, the 17q24.3 locus had been genetically linked to TPP, in which the genetic variant rs312691 (TC genotype) in long intergenic noncoding RNA (lincRNA) CTD-2378E21.1 is located downstream of inward-rec...

Pada penelitian ini, mikroenkapsulasi β-karoten dilakukan dalam matriks campuran pati dan kitosan dengan penambahan ion tripolifosfat sebagai pengikat silang (dilambangkan pati-kitosan/TPP). Dua jenis yang digunakan di sini, yaitu asli terhidrolisis. Pati terhidrolisis dibuat hidrolisis asam menggunakan HCl 2 M. Mikrokapsul disintesis menambahkan dispersi tetes demi etanol ke pati-kitosan/TPP d...

Traumatic pulmonary pseudocyst (TPP) is a rare complication, sometimes encountered after blunt thoracic trauma and even more rarely following penetrating injuries. It is more common among pediatric and young adult patients. Although TPP is usually benign in nature, complications associated with hemoptysis and secondary infection may develop. The treatment is conservative. In this report, we pre...

Thyrotoxic periodic paralysis is a rare complication of hyperthyroidism, characterized by severe hypokalemia and episodes of skeletal muscle paralysis. Although it is commonly described in adult East Asian men, TPP has been reported in individuals of all ages and ethnic backgrounds. We describe the case of a young adult Hispanic male who presented to a Pediatric Emergency Department with paraly...

In the current work, in continuation of our recent research, we synthesized and studied new chimeric compounds, including ribosome-targeting antibiotic chloramphenicol (CHL) membrane-penetrating cation triphenylphosphonium (TPP), which are linked by alkyl groups different lengths. Using various biochemical assays, showed that these CAM-Cn-TPP compounds bind to bacterial ribosome, inhibit protei...

1. The TPP is of critical importance to Taiwan. Its importance and implications are reflected in three major aspects. First is the economic implication if Taiwan joins (or failed to join) the TPP bandwagon. Second is the implication on domestic reforms, i.e. using TPP as a driving force for Taiwan to undertake reform initiatives. Last but not least is the political implication for Taiwan as a p...

Age-related macular degeneration (AMD) is the leading cause of certified vision loss worldwide. The standard treatment for neovascular AMD involves repeated intravitreal injections of therapeutic proteins directed against vascular endothelial growth factor, such as ranibizumab. Biodegradable polymers, such as poly(lactic-co-glycolic acid) (PLGA), form delivery vehicles which can be used to trea...

The comparative X-ray absorption spectroscopy study of gadolinium and samarium bisporphyrinate complexes represented by the formulas Gd(III)H(oep)(tpp), Gd(III)(oep)(2), Gd(III)H(tpp)(2) and Sm(III)H(oep)(tpp), Sm(III)(oep)(2), Sm(III)H(tpp)(2) is reported. The XAFS spectra are recorded on the LURE-DCI storage ring (Orsay, France) in transmission mode on the microcrystalline samples at the Gd a...

We introduce the track parallelization problem (TPP) that consists in parallelizing the execution of task sets. For modelling and solving TPPs in a finite-domain constraintprogramming framework, we propose the TPP constraint along with a suitable solver for use in non-preemptive scheduling. We demonstrate how to infer redundant TPPs in school timetabling and we report a large-scale empirical st...