Muscle protein synthesis (MPS) rate is determined conventionally by obtaining two or more tissue biopsies during a primed, continuous infusion of a stable isotopically labeled amino acid. The purpose of the present study was to test whether tracer priming given as a flooding dose, thereby securing an instantaneous labeling of the tissue pools of free tracee amino acids, followed by a continuous...

Hydraulic dispersion in porous media and in fracture networks results in the spreading of the timedependent tracer signal. In geothermal reservoirs the wellbore often intersects fractures that are separated by tens or even hundreds of meters. The mixing in the wellbore at those separated fractures is also a source of dispersion, since tracer signals sampled at the wellhead are a mixture of the ...

Hydraulic fracturing is an effective technique for increasing the productivity of wells producing from low permeability formations. Tracer fracture monitoring technique is near-wellbore zone frctures direct test method that can monitor the height and width of hydraulic fractures in the near-wellbore section. ZeroWash Tracer uses a medium strength ceramic proppant which is mainly used in fractur...

Stream water was locally recharged into shallow groundwater flow paths that returned to the stream (hyporheic exchange) in St. Kevin Gulch, a Rocky Mountain stream in Colorado contaminated by acid mine drainage. Two approaches were used to characterize hyporheic exchange: sub-reach-scale measurement of hydraulic heads and hydraulic conductivity to compute streambed fluxes (hydrometric approach)...

Consideration is given to the role of a population of muscle fibers of distributed diameters in the observed washout of a tracer, with particular reference to radioisotopic K and muscle fibers. It is concluded that if washout of tracer from a single fiber is described as first order, then washout of tracer from a population of fibers is apt to appear as first order.

Introduction: 64Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (64Cu-PTSM)‍ is one of the most important copper radiopharmaceuticals used in clinical experiments. Methods: In this work, copper-64 (T1/2=12.33 h) production has been presented followed by the synthesis of the complexing agent, PTSM, and its structure was confirmed by common spectroscopic methods followed by radiolabeling w...

An appropriate receptor-targeted tracer for sentinel lymph node biopsy (SLNB) was prepared. We combined the fluorescence tracer (Indocyanine green, ICG) with Rituximab (a chimeric human/murine monoclonal antibody targeting the CD20 antigen on the surface of lymphocyte) directly to produce a new tracer (ICG-Rituximab). When the new tracer drains to the lymph node, Rituximab will combine with CD2...

INTRODUCTION An (18)F-labeled positron emission tomography (PET) tracer for amyloid plaque is desirable for early diagnosis of Alzheimer's disease, particularly to enable preventative treatment once effective therapeutics are available. Similarly, such a tracer would be useful as a biomarker for enrollment of patients in clinical trials for evaluation of antiamyloid therapeutics. Furthermore, c...

Purpose: In this project, we developed novel methods to quantify changes in tumor hypoxia following a mild temperature hyperthermia (MTH) treatment in rat HT29 human colon adenocarcinoma xenograft. Materials and Methods: An exogenous hypoxia marker (IAZGP) was labeled with two radioisotopes of iodine (I and I, respectively) to form two distinct tracers. The two tracers were injected into HT29-b...

In studies where D-(-)-3-hydroxy[4,4,4-2H3]butyrate is employed as isotopic tracer in vivo, we have described a selected ion monitoring, gas-liquid chromatography-mass spectrometry micromethod which measures [2H3] tracer enrichment in 3-hydroxybutyrate and acetoacetate from 300-microliters blood samples. For plasma samples in the physiologic range, intra- and interassay precisions for each keto...