يمومع باي تيعقوم متسيس كي تقد 3 رد متسيس وردوخ يربوان ياه يم ريثأت يفلتخم لماوع زا زا تـسا مزلا لـيلد نيمه هب و دريذپ شور دومن هدافتسا وردوخ هدش نييعت تيعقوم رد تقد شيازفا تهج هشقن قيبطت ياه . متسيس رد هشقن قيبطت وردوـخ يربواـن ياـه دراد هدهع رب ار رهش هشقن يوررب وردوخ يلعف تيعقوم نييعت هفيظو . رد هـشقن قيبطت هلأسم لح يارب يبيكرت متيروگلا كي هلاقم نيا متسيس رد يم داهنشيپ وردوخ يربوان يا...

Various atrophic stimuli increase two muscle-specific E3 ligases, muscle RING finger 1 (MuRF1) and atrogin-1, and knockout mice for these "atrogenes" display resistance to denervation-induced atrophy. The present study determined whether increased atrogin-1 and MuRF1 mRNA are mediated by overproduction of endogenous glucocorticoids or inflammatory cytokines in adult rats and whether atrogene ex...

BACKGROUND Muscle ring finger 1 (MuRF1) is a muscle-specific ubiquitin E3 ligase activated during clinical conditions associated with skeletal muscle wasting. Yet, there remains a paucity of therapeutic interventions that directly inhibit MuRF1 function, particularly in vivo. The current study, therefore, developed a novel compound targeting the central coiled coil domain of MuRF1 to inhibit mu...

Exposure to chronic hypoxia (CH) induces elevated pulmonary artery pressure/resistance, leading to an eventual maladaptive right ventricular hypertrophy (RVH). Muscle RING finger-1 (MuRF1) is a muscle-specific ubiquitin ligase that mediates myocyte atrophy and has been shown to play a role in left ventricular hypertrophy and altered cardiac bioenergetics in pressure overloaded hearts. However, ...

Sequestosome 1/p62 is a scaffolding protein with several interaction modules that include a PB1 dimerization domain, a TRAF6 (tumor necrosis factor receptor-associated factor 6) binding site, and a ubiquitin-associating (UBA) domain. Here, we report that p62 functions to facilitate K63-polyubiquitination of TRAF6 and thereby mediates nerve growth factor-induced activation of the NF-kappaB pathw...

OBJECTIVE To investigate the prognostic significance of tumor necrosis factor receptor (TNFR),-associated factor 6 (TRAF6),-and ubiquitin in gastric cancer patients. METHODS Biopsies of the rectus abdominis muscle were obtained intra operatively from 102 gastric cancer patients and 29 subjects undergoing surgery for benign abdominal diseases, and muscle TRAF6 and ubiquitin mRNA expression and...

Signaling through its widely distributed cell surface receptor, interleukin (IL)-17 enhances the transcription of genes encoding proinflammatory molecules. Although it has been well documented that IL-17 activates the transcription factor nuclear factor (NF)-kappaB and c-Jun NH(2)-terminal kinase (JNK), the upstream signaling events are largely unknown. Here we report the requirement of tumor n...

ةصلاخلا بكرملل ةدیدج تاقتشم ریضحت ىلا ثحبلا يمری 4,3,1 ةیتلاا تلاعافتلا ءارجا للاخ نم لوزایادایاث : ًلاوأ : ب كرملل فیش ةدعاق ریضحت ) 2 و نیما 5 و تبكرم 4,3,1 لوزا یادایاث ( يلیفو یلكوینلا ضیو عتلا ءارجاو ةدعاقلل يرتسلاا ب كرملا نیو كت ى لا يدؤ یل مویدو صلا دیسكوثیا دو جوب ل ثیلاا تاتیسا ومورب عم ) 3 ( ، يذ لا یازاردیھلا عم ھتلعافم تمت ن 99 % د یازاردیھلا قتشم ریضحتل ) 4 ( فیش دعاوق نم د یدع...

Tumor necrosis factor receptor-associated factor 6 (TRAF6) is one of the key adapter molecules in Toll-like receptor signal transduction that triggers downstream cascades involved in innate immunity. In the present study, a TRAF6 (named as Et-TRAF6) was identified from the marine fish grouper, Epinephelus tauvina by RACE PCR. The full-length cDNA of Et-TRAF6 comprised 1949 bp with a 1713 bp ope...

Both autophagy and apoptosis are essential processes participating in cell death maintain cellular homeostasis. The dysregulation of these two biological results development diseases including cancers. Therefore, targeting nodes crosstalk between is a potential strategy for cancer therapy. Melanoma the most lethal skin accounting over 80% deaths. We previously identified tumor necrosis factor r...