OBJECTIVE A meta-analysis was performed to investigate the effectiveness and safety of tranexamic acid (TXA) for the treatment of blood loss after a bilateral total knee arthroplasty (TKA). METHODS Patients prepared for bilateral TKA and intervention including TXA versus placebo were comprehensively retrieved from MEDLINE (PubMed), Embase, Cochrane Central Register of Controlled Trials (CENTR...

To assess the safety and efficacy of tranexamic acid (TXA) for decreasing perioperative blood loss in cervical laminectomy with lateral mass screw fixation and bone grafting (CLF), in which all surgical procedures are identical.From November 2014 to April 2016, we performed a retrospective comparative analysis of 119 patients with multilevel cervical spondylotic myelopathy who had undergone a C...

BACKGROUND The purpose of this meta-analysis is to compare the efficacy of tranexamic acid (TXA) versus placebo after a total shoulder arthroplasty (TSA). METHODS In April 2017, a systematic computer-based search was conducted in the databases of PubMed, Embase, Web of Science, Cochrane Library, and Google. Studies comparing TXA versus placebo in reducing blood loss after TSA were included. T...

OBJECTIVES To evaluate the efficacy and safety of intra-articular Soaking of high concentration Tranexamic Acid (TXA) in total hip arthroplasty. METHODS From March 2013 to March 2014, 224 patients who underwent unilateral primary THA in our hospital was enrolled in this randomized, prospective double-blinded study. The patients were allocated into two groups according to intra-articular solut...

Abstract Due to its anti-fibrinolytic action, tranexamic acid (TXA) can be utilized help maintain hemostasis during surgical operations. With respect surgery for intracranial tumors, we hypothesize that TXA could mitigate blood loss resection of highly vascular tumors such as meningiomas. We therefore conducted a systematic review the literature and meta-analysis analyze effects administration ...

PURPOSE Intraoperative blood loss in scoliosis surgery often requires transfusions. Autogenous blood decreases but does not eliminate risks typically associated with allogenic blood transfusion. Costs associated with transfusions are significant. Tranexamic acid (TXA) has been shown to decrease blood loss in cardiac and joint surgery. Few studies have examined its use in pediatric spine surgery...

Purpose: To investigate the efficacy of exogenous recombined human erythropoietin (rhEPO), combined with tranexamic acid (TXA) and administered by different routes, in treatment elderly patients femoral intertrochanteric fractures.Methods: 252 Suzhou Xiangcheng People's Hospital were randomly divided into groups (A, B C), 84 each group. All given rhEPO iron sucrose, followed TXA which was via t...

Aim: The aim of the study was to compare efficacy intravenous (IV) administration tranexamic acid (TXA) in terms bleeding volume, allogeneic blood transfusion (ABT) requirement, and complications total hip arthroplasty (THA) secondary osteoporotic femoral neck fracture (FNF).
 Material Method: A 165 patients who underwent THA on background FNF our clinic were included study. Patients' demo...

BACKGROUND Evidence on prehospital administration of the antifibrinolytic tranexamic acid (TXA) in civilian trauma populations is scarce. The aim was to study whether prehospital TXA use in trauma patients was associated with improved outcomes. METHODS The prehospital database of the ADAC (General German Automobile Club) Air Rescue Service was linked with the TraumaRegister of the German Trau...

BACKGROUND Recently, a number of studies using intra-articular application of tranexamic acid (IA-TXA), with different dosage and techniques, successfully reduced postoperative blood loss in total knee replacement (TKR). However, best of our knowledge, the very low dose of IA-TXA with drain clamping technique in conventional TKR has not been yet studied. This study aimed to evaluate the effecti...