Isoflavonoids and the related synthesis enzyme, chalcone isomerase 1 (CHI1), are unique in the Leguminosae, with diverse biological functions. Among the Leguminosae, the soybean is an important oil, protein crop, and model plant. In this study, we aimed to detect the generation pattern of Leguminosae CHI1. Genome-wide sequence analysis of CHI in 3 Leguminosae and 3 other closely related model p...

A chimeric gene construct containing a bean chalcone synthase (CHS) promoter fused to the chloramphenicol acetyltransferase (CAT) reporter gene was strongly expressed when electroporated into alfalfa protoplasts that were then exposed to a fungal elicitor. Low concentrations (5 x 10(-6) to 10(-4) M) of exogenously applied trans-cinnamic acid (CA), the first intermediate of the phenylpropanoid p...

Several applications of chalcones and their derivatives encouraged researchers to increase their synthesis as an alternative for the treatment of pathogenic bacterial and fungal infections. In the present study, chalcone derivatives were synthesized through cross aldol condensation reaction between 4-(N,N-dimethylamino)benzaldehyde and multiarm aromatic ketones. The multiarm aromatic ketones we...

Hepatocellular carcinoma (HCC) is one of the most commonly diagnosed cancers worldwide. Chemoprevention of HCC can be achieved through the use of natural or synthetic compounds that reverse, suppress or prevent the development of cancer progression. In this study, we investigated the antiproliferative effects and the mechanism of action of two compounds, 2,3,4'-trimethoxy-2'-hydroxy-chalcone (C...

Synthesis of 2’,4’-dihydroxy-3,4-dimethoxychalcone and in vitro test its sunscreen activity have been carried out. Chalcone was synthesized from 3,4-dimethoxybenzaldehyde 2,4-dihydroxyacetophenone through Claisen-Schmidt condensation. The synthesis performed by using KOH 40% under stirring at room temperature for 48 h. compounds characterized FTIR, GC-MS 1H NMR spectrometers. Further, the chalc...

Chalcone-derived pyrimidine is a well-known heterocyclic compound that commonly present in ribonucleic acid (RNA) and deoxyribonucleic (DNA) bio-isosteres. Pyrimidine derivatives are effective both the electronic industry drug industries. This review highlights synthesis of pyrimidines, namely mono-pyrimidine, bis-pyrimidine, fused pyrimidine, symmetric, asymmetric via one-pot two-pot methods. ...

a new type of magnetically-recoverable catalyst was synthesized by the immobilization of h3pw12o40 on the surface of silica-encapsulated -fe2o3 nanoparticles. a series of novel 1,3,5-triaryl pyrazoline derivatives has been synthesized by the reaction of chalcone and phenylhydrazine in the presence of the -fe2o3@sio2-pw12nanoparticles,  in high yields. the structures of compounds obtained were...

γ-Valerolactone as a renewable, polar aprotic solvent was evaluated in the selective hydrogenation of carbon-carbon double bond chalcones from both catalytic and mechanistic aspects. By using triphenylphosphine-modified cationic rhodium catalyst systems reasonably high activities (TOFinitial∼1200 h−1) were achieved (E)-chalcone (CHL), common model substrate for α,β-unsaturated ketones, to dihyd...

Background: Streptococcus mutans is one of the most important microorganisms in tooth decay. Sortase A (SrtA) S. responsible for attachment bacteria to host cell and biofilm formation. Therefore, it seems necessary investigate inhibitors this enzyme prevent dental caries. Chalcones are always interest medical community due their wide range biological activities. Many studies have reported that ...

New cDNA sequences for chalcone synthase (CHS), a key enzyme in the flavonoid biosynthesis, were obtained from the Japanese and common morning glories; they are more closely related to other CHS sequences than the six previously described CHS genes from the same plants. The newly isolated CHS-D gene is abundantly expressed in the pigmented flower buds, while its expression is drastically reduce...