OBJECTIVES To evaluate the effect of Donepezil on cerebral blood flow velocity using non-invasive transcranial Doppler (TCD) sonography. METHODS This clinical trial was carried out in the Department of Neurology, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran from March 2008 to July 2009, on Alzheimer's disease (AD) patients in 2 groups of case and control, each consi...

Abbreviations: patent foramen ovale, PFO; transcranial Doppler ultrasonography, TCD; Global initiative for chronic Obstructive Lung Disease, GOLD; partial pressure of oxygen, PaO2; oxygen uptake, V’O2; high-intensity transient signals, HITS Funding Support: Not Applicable. Citation: Fenster BE, Carroll JD. Patent foramen ovale in COPD and hypoxia: Innocent bystander or novel therapeutic target?...

Cerebrovascular reactivity (CR) assessed by transcranial Doppler (TCD) has been evaluated among migraineurs with conflicting results. We assessed the CR using the breath holding index (BHI) among 228 migraineurs during ictal or interictal phase and 56 controls. Migraineurs exhibited increased BHI values in the interictal phase and reduced BHI in the ictal phase when compared to controls.

BACKGROUND Cerebral vasospasm (VSP) is a common complication after subarachnoid hemorrhage (SAH), but has rarely been reported after intracerebral hemorrhage (ICH) without subarachnoidal bleeding. The underlying pathophysiological mechanism is mainly mediated by circulating heme products within the cerebrospinal fluid, and thus patients with ICH and ventricular involvement (IVH) may also be in ...

BACKGROUND A high incidence of clinically-silent cerebral ischemic events has been reported in splenectomised patients with β-thalassemia intermedia (βTI). These could be due to cerebral large-vessel disease. Based on the example of sickle cell disease, we applied transcranial Doppler sonography (TCD) to evaluate cerebral vessels velocity as a possible indicator of cerebral vasculopathy. PATI...

OBJECTIVE The purpose of this study was to evaluate hemispheric asymmetry of cerebral blood flow changes during various mental tests by applying transcranial Doppler sonography (TCD) to simultaneously monitor bilateral cerebral blood flow velocity changes. METHODS Twenty-one participants without cerebrovascular disease performed 3 left hemispheric tasks (reading, calculation, and color scalin...

Investigating how intrathoracic pressure changes affect cerebral blood flow (CBF) is important for a clear interpretation of neuroimaging data in patients with abnormal respiratory physiology, intensive care patients receiving mechanical ventilation and in research paradigms that manipulate intrathoracic pressure. Here, we investigated the effect of experimentally increased and decreased intrat...

OBJECTIVE To observe the therapeutic effect of acupuncture plus Ligustrazine on vertebrobasilar insufficiency (VBI) by transcranial Doppler (TCD) sonography. METHODS 86 VBI patients including 56 cases of low flow rate velocity type (LFVT) and 30 cases of high flow velocity type (HFVT) were randomly divided into Ligustrazine group (26 LFRT and 14 HFVT) and acupuncture plus Ligustrazine group (...

microembolic signals (mes) are frequently observed in transcranial ‎doppler (tcd) recordings of patients with mechanical heart valve (mhv). if gaseous bubbles are the underlying cause, number of mes produced by mhv could be reduced with oxygen ‎inhalation. from september 2003 to september ‎2004, a consecutive series of 14 patients ‎with st jude aortic valve visited in the cardiology clinic were...

BACKGROUND AND PURPOSE Recent investigations have suggested an important role of statins in the prevention of stroke and dementia independent of their lipid-lowering properties. Using transcranial Doppler sonography (TCD), we examined acetazolamide reactivity as a marker of cerebral vasoreactivity in patients with subcortical small-vessel disease before and after pravastatin treatment. METHOD...