We show that within the same age cohort, growth rates of young firms are strongly increasing in firm size. This robust empirical pattern is confined to the initial years after entry; growth rates become independent of size as a cohort matures, as predicted by Gibrat’s law of proportionate growth. Both the initial pattern and the subsequent convergence are consistent with the framework of the pa...

We establish a variety of combinatorial bounds on the tradeoos inherent in reconstructing strings using few rounds of a given number of substring queries per round. These results lead us to propose a new approach to sequencing by hybridization (SBH), which uses interaction to dramatically reduce the number of oligonucleotides used for de novo sequencing of large DNA fragments, while preserving ...

MOTIVATION The de novo assembly of large, complex genomes is a significant challenge with currently available DNA sequencing technology. While many de novo assembly software packages are available, comparatively little attention has been paid to assisting the user with the assembly. RESULTS This article addresses the practical aspects of de novo assembly by introducing new ways to perform qua...

one of the best strategies to control bacterial wilt caused by ralstonia solanacearum (smith) is generally based on breeding resistant cultivars. the information obtained from the expression of plant defense genes will provide new insight for improving plant resistance against pathogens. this study was to identify inducible genes under defense no death (dnd) reaction of tobacco (nicotiana tabac...

Recently, the technologies of DNA sequence variation and gene expression profiling have been used widely as approaches in the expertise of genome biology and genetics. The application to genome study has been particularly developed with the introduction of the next-generation DNA sequencer (NGS) Roche/454 and Illumina/Solexa systems, along with bioinformation analysis technologies of whole-geno...

Entry in Telecommunication: Customer Loyalty, Price Sensitivity and Access Prices* The purpose of this article is to investigate the prospects for entry into an existing network in the telecommunication industry, and how public policy may promote a more competitive outcome. We apply a model that captures the fact that the incumbent has an installed base of loyal consumers, that some consumers a...

De novo rates and selection of large copy number variation Andy Itsara, Hao Wu, Joshua D. Smith, Deborah A. Nickerson, Isabelle Romieu, Stephanie J. London, and Evan E. Eichler Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington 98195, USA; National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Hum...