Transdermal and dermal drug delivery is problematic because the skin, as a natural barrier, has a very low permeation rate. Therefore several methods have been assessed to increase this rate locally and temporarily. One approach is the use of vesicle formulations. In this paper the effectiveness of conventional and deformable vesicles as drug delivery systems as well as their possible mode of a...

Nowadays about 74% of drugs are taken orally and found not to be as effective required. To improve such characters transdermal drug delivery system was emerged. Drug through the skin attain a systemic effect is commonly known differs from traditional topical delivery. Transdermal systems (TDDS) dosage forms involves transport viable epidermal or dermal tissues for local therapeutic while very m...

Although sildenafil citrate (SC) is used extensively for erectile dysfunction, oral delivery of SC encounters many obstacles. Furthermore, the physicochemical characteristics of this amphoteric drug are challenging for delivery system formulation and transdermal permeation. This article concerns the assessment of the potential of nanomedicine for improving SC delivery and transdermal permeation...

BACKGROUND Psoriasis is an autoimmune disease that is caused by a shift in the Th1/Th2 balance toward Th1-dominant immunity. It has been established as an effective treatment to counteract psoriasis by subcutaneous injection of recombinant interleukin (IL)-4, and IL-4 gene therapy by topical transdermal penetration has shown its antipsoriatic effect in mice. Retinoic acid (RA) and dimethylsulfo...