background: asymptomatic malaria infection provides a reservoir of parasites, causing the persistence of malaria transmission. it accounts an important challenge for successful management of the control, elimination, and eradication programmes in any malaria-endemic region. this investigation was designed to assess the presence and the prevalence of asymptomatic carriers in iranshahr district o...

Background It is believed that in many cases Food allergy (FA) develops due to the contact of the immune system with different allergens through affected skin and mucous barriers. Studies of the filaggrin mutations in atopic dermatitis showed informativity of the transepidermal water lost measurement (TEWL) in assessment of the skin barrier condition. Faecal calprotectin is marker of the inflam...

We report herein two cases of intractable atopic dermatitis successfully treated by simply avoiding the contact with surface-active detergents in the daily life and living. The detergents were closely related to the exacerbation and remission of the disease. Steroid ointment was no longer used. We discuss that the removal of horny layer lipids by surface-active detergents accelerates the transe...

this study was undertaken to identify key elements for obtaining community interest and motivate them to support eliminate malaria in the places that malaria is no longer a perceived threat.sequential explanatory mixed methods research design used to provide more comprehensive evidence research. a questionnaire was developed after reviewing the literature relating to community participation for...

Transglutaminase 1 (TGase 1) is one of the genes implicated in autosomal recessive congenital ichthyosis. Skin from TGase 1(-/-) mice, which die as neonates, lacks the normal insoluble cornified envelope and has impaired barrier function. Characterization of in situ dye permeability and transepidermal water loss revealed defects in the development of the skin permeability barrier in TGase 1(-/-...

This review presents recent evidence of impaired Notch signalling in atopic dermatitis (AD), which is proposed to represent the "a-topic" defect linking both epidermal and immunological barrier dysfunctions in AD. AD epidermis exhibits a marked deficiency of Notch receptors. Mouse models with genetically suppressed Notch signalling exhibit dry skin, signs of scratching, skin barrier abnormaliti...

BACKGROUND This study examines the efficacy of a new plant-based emollient and assesses product acceptability. METHODS Primary efficacy endpoints were improvement in transepidermal water loss, hydration, skin elasticity and firmness, erythema, and skin roughness and smoothness as measured using the versions of Tewameter, Corneometer, Cutometer, Mexameter, and Visioscan VC98, respectively. The...

OBJECTIVE Facial aging is characterized by skin laxity and loss of skin elasticity. Hyaluronic acid, a biological component of the extracellular matrix, whose level decreases during aging, plays structural, rheological, and physiological roles in the skin. Hyaluronic acid may possess different molecular weights: low-molecular-weight hyaluronic acid (from 50 kDa) and high-molecular-weight hyalur...