Abstract Aim To improve a general surgical department's adherence to NICE guidelines on transfusion of packed red cells for low haemoglobin by improving knowledge relevant thresholds (70g/L or 80g/L in ACS renal failure requiring chronic transfusion). Method All patients admitted large London teaching hospital under the team 4-month period (2020–2021) were audited using their electronic records...

Graft survival after 348 consecutive first cadaver-donor renal transplants was significantly improved by HLA matching when recipients who had received pretransplant blood transfusions were matched with their kidney donor for two HLA-B locus antigens. No other type of HLA matching significantly improved graft survival in transfused recipients nor did any type of HLA matching in non-transfused re...

BACKGROUND Alloimmunization is an adverse effect of blood transfusions. In Chile, alloimmunization frequency is not established, and for this reason the aim of this study was to investigate the prevalence and specificity of red blood cell (RBC) alloantibodies in Chilean transfused subjects. METHODS Records from 4,716 multi-transfused patients were analyzed. In these patients, antibody screeni...

INTRODUCTION The aim of this study was to assess the efficacy of two dosing schedules of recombinant human erythropoietin (rHuEPO) in increasing haematocrit (Hct) and haemoglobin (Hb) and reducing exposure to allogeneic red blood cell (RBC) transfusion in critically ill patients. METHOD This was a prospective, randomized, multicentre trial. A total of 13 intensive care units participated, and...

results of 153 patients, 96.8% received pc and 54.9% transfused ffp during or after surgery. most of the transfusions were done after operation in intensive care unit (icu). also, 20% and 17% of the patients underwent transfusion of more than 6 units of pc and ffp, respectively. the mean left ventricular ejection fraction of the patients was 42.5 ± 10.9%. a significant number of patients had an...

BACKGROUND Severity of illness is an important consideration in making the decision to transfuse as it is the sicker patient that often needs a red cell transfusion. Red blood cell (RBC) transfusions could potentially have direct effects and interact with presenting illness by contributing to pathologies such as multi-organ dysfunction and acute lung injury thus exerting a considerable impact o...

OBJECTIVE To predict how much blood will be needed based on the number of injured patients arriving after a multiple-casualty incident. DESIGN A retrospective study evaluating data collected in 18 consecutive terrorist attacks in the city of Tel Aviv between January 1997 and February 2005. SETTING A large, urban trauma center. PATIENTS A total of 986 patients in 18 events. MAIN OUTCOME ...

Eighteen human immunodeficiency virus (HIV)-seropositive patients were found among 211 previously treated adult patients with a variety of leukemias who had been multiply transfused before April 1985. Patients known to be homosexual or intravenous drug users were excluded from this study. The spouse of one HIV-seropositive patient became HIV infected and subsequently developed the acquired immu...

BACKGROUND Aprotinin is frequently used in high-risk cardiac surgery patients to decrease bleeding complications and transfusions of packed red blood cells (PRBC). Transfusions of PRBC are known to directly increase the risk of new onset postoperative renal failure (ARF) in cardiac surgery patients. A recent highly publicized report implicated aprotinin as an independent causal factor for posto...

Magnetic resonance imaging (MRI) has played a key role in studies of iron overload in transfusion-dependent patients, providing insights into the relations among liver and cardiac iron loading, iron chelator dose, and morbidity. Currently, there is rapid uptake of these methods into routine clinical practice as part of the management strategy for iron overload in regularly transfused patients. ...