The regulation of TT virus (TTV) gene expression was characterized. Transient-transfection assays using reporter constructs revealed that a 113-nucleotide (nt) sequence within the untranslated region, proximal to the transcription initiation site and containing a TATA box motif, has a basal promoter activity. This sequence is well conserved among different TTV genotypes. Upstream stimulating fa...

OBJECTIVE To investigate the rate of infection caused by Torque teno virus (TTV) in United Arab Emirates (UAEs) healthy population as a pilot study in detecting TTV DNA in 100 healthy blood donors. METHODS We randomly choose a total of 100 healthy blood donors who attended Zayed Military Hospital, Abu Dhabi, UAE from January 20 to May 30, 2005. We carried out a real-time polymerase chain reac...

Torque teno viruses (TTVs), of the genus Anellovirus, are single-stranded circular DNA viruses that infect many vertebrate species. Although viruses of this type have quite a stable genome, they exhibit low nucleotide homology. Torque teno virus infection has not been consistently linked to specific diseases, although there is epidemiological evidence of an association with disease in humans. T...

The sequence data (H. Okamoto et al., Hepatol. Res. 10:1-16, 1998) of a newly discovered single-stranded DNA virus, TT virus (TTV), showed that it did not have the terminal structure typical of a parvovirus. Elucidation of the complete genome structure was necessary to understand the nature of TTV. We obtained a 1.0-kb amplified product from serum samples of four TTV carriers by an inverted, ne...

TTV has been recently identified as a causative agent of non-A to non-G hepatitis. However, the exact role of this virus in the pathogenesis of chronic liver disease (CLD) and the development of hepatocellular carcinoma (HCC) remain controversial. To clarify these issues, the prevalence of this virus and its impact on the severity of liver disease and development of HCC among Egyptian patients ...

TT virus (TTV) and TTV-like minivirus (TLMV) are small DNA viruses with single-stranded, closed circular, antisense genomes infecting man. Despite their extreme sequence heterogeneity (>50%), a highly conserved region in the untranslated region (UTR) allows both viruses to be amplified by polymerase chain reaction (PCR). TTV/TLMV infection was detected in 88 of 100 human plasma samples; amplifi...

conclusions in conclusion, the prevalence of hbv infection was low in the south of iran, but genotype d represented the major hbv genotype in this population. among the variables, age, duration of hd, history of blood transfusion, and using shared hd devices influenced the prevalence of hbv among hd patients. results both kinds of assay determined that nine (5.88%) patients were hbv positive (h...