Ca2+ signals in cardiac muscle cells are composed of spatially limited elementary events termed Ca2+ sparks. Several studies have also indicated that Ca2+ signals smaller than Ca2+ sparks can be elicited. These signals have been termed Ca2+ quarks and were proposed to result from the opening of a single Ca2+ release channel of the sarcoplasmic reticulum. We used laser-scanning confocal microsco...

A large fraction of endocytosis in eukaryotic cells occurs without adaptors or dynamins. Here, we present evidence for the involvement of lipid domains in massive endocytosis (MEND) activated by both large Ca transients and amphipathic compounds in baby hamster kidney and HEK293 cells. First, we demonstrate functional coupling of the two MEND types. Ca transients can strongly facilitate deterge...

Manipulation of electron dynamics calls for electromagnetic forces that can be confined to and controlled over sub-femtosecond time intervals. Tailored transients of light fields can provide these forces. We report on the generation of subcycle field transients spanning the infrared, visible, and ultraviolet frequency regimes with a 1.5-octave three-channel optical field synthesizer and their a...

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Early interpretations of the variability of the narrow 0.511 MeV annihilation line from the Galactic center (GC) were confused by the unrecognized presence of a very extended component (mid 70s | mid 80s). Transient behavior was suggested by comparisons of measurements made by instruments with comparable elds of view, and by detection of other lines which could be interpreted as broadened and D...

A study of the transient (chronoamperometric) response of the scanning electrochemical microscope (SECM) is presented. SECM transients were simulated digitally with a novel integrator based on a Krylov algorithm. The transients observed with planar electrodes (PE), microdisks (MD), and thin-layer cells (TLC) are shown to be limiting cases that fit the simulated SECM transients at very short, in...

Gamakas are an integral aspect of Carnatic Music, a form of classical music prevalent in South India. They are used in rāgas, which may be seen as melodic scales and/or a set of characteristic melodic phrases. Gamakas exhibit continuous pitch variation often spanning several semitones. In this paper, we study how gamakas scale with tempo and propose a novel approach to change the tempo of Carna...

We present a flexible analysis/synthesis tool for transient signals that extends current sinusoidal and sines+noise models for audio to sines+transients+noise. The explicit handling of transients provides a more realistic and robust signal model. Because the transient model presented is the frequency domain dual to sinusoidal modeling, it has similar flexibility and allows for a wide range of t...

BACKGROUND Transient atrial contractile dysfunction ("atrial stunning") follows conversion of atrial fibrillation (AF) to sinus rhythm and has significant clinical implications; however, the underlying mechanisms are poorly understood. We investigated the hypothesis that rapid atrial activation (as during AF) impairs cellular contractility and affects cellular Ca2+ handling. METHODS AND RESUL...