Radiation-induced lung injury (RILI) is one of the most common and fatal complications of thoracic radiotherapy. It is characterized with two main features including early radiation pneumonitis and fibrosis in later phase. This study was to investigate the potential radioprotective effects of polydatin (PD), which was shown to exert anti-inflammation and anti-oxidative capacities in other disea...

New research data for low-dose, low-linear energy transfer (LET) radiation-induced, stochastic effects (mutations and neoplastic transformations) are modeled using the recently published NEOTRANS(3) model. The model incorporates a protective, stochastic threshold (StoThresh) at low doses for activating cooperative protective processes considered to include presumptive p53-dependent, high-fideli...

Electrons crossing the boundary between different media generate bursts of transition radiation. In the case of bunches of N electrons, the radiation is coherent and has an N-squared enhancement at wavelengths related to the longitudinal bunch distribution. This coherent transition radiation has therefore attracted attention as an interceptive charged particle beam diagnostic technique. Many an...

Coherent radiation emitted from a compressed electron bunch as it traverses the sharp edge regions of a magnetic chicane has been investigated at the Brookhaven National Laboratory Accelerator Test Facility. Electron beam measurements using coherent transition radiation interferometry indicate a 100 fs rms bunch accompanied by distinct distortions in energy spectrum due to strong self-fields. T...

Transient generation of reactive oxygen or nitrogen (ROS/RNS), detected with dihydrodichlorofluoroscein by fluorescence microscopy, occurs within minutes of exposing cells to ionizing radiation. In the 1-10 Gy dose range, the amount of ROS/RNS produced/cell is constant, but the percentage of producing cells increases with dose (20 to 80%). Reversible depolarization of the mitochondrial membrane...

A facility to generate high-intensity, ultra-short pulses of broad-band far-infrared radiation has been assembled and tested at Stanford.’ The device uses sub-picosecond relativistic electron bunches to generate coherent radiation through transition or synchrotron radiation in the far-infrared (FIR) regime between millimeter waves and wavelengths of about 100pm and less. Experimental results sh...

Spectral measurements of visible coherent transition radiation produced by a laser-plasma-accelerated electron beam are reported. The significant periodic modulations that are observed in the spectrum result from the interference of transition radiation produced by multiple bunches of electrons. A Fourier analysis of the spectral interference fringes reveals that electrons are injected and acce...

Epithelial to mesenchymal transition (EMT) is developmental process associated with cancer metastasis. Here, we found that breast carcinoma cells adopt epithelial-to-mesenchymal transition (EMT) in response to fractionated-radiation. Importantly, we show that Notch signaling is highly activated in fractionally-irradiated tumors as compared to non-irradiated tumors that are accompanied by an EMT...

Sonoluminescence is explained in terms of quantum radiation by moving interfaces between media of different polarizability. It can be considered as a dynamic Casimir effect, in the sense that it is a consequence of the imbalance of the zero-point fluctuations of the electromagnetic field during the non-inertial motion of a boundary. The transition amplitude from the vacuum into a two-photon sta...