A diffusion barrier at the transition zone enables the compartmentalization of signaling molecules by cilia. The BBSome and the small guanosine triphosphatase Arl6, which triggers BBSome coat polymerization, are required for the exit of activated signaling receptors from cilia, but how diffusion barriers are crossed when membrane proteins exit cilia remains to be determined. In this study, we f...

[1] Teleseismic receiver function analysis of data from six dense arrays in the western U.S. is used to inves­ tigate mantle transition zone (MTZ) discontinuities and the prevalence of a low‐velocity layer atop the 410 km discontinuity (410‐LVL). Negative polarity Ps arrivals indicative of a low‐velocity layer with a top 25–60 km above the 410 are identified in 8–11 out of 18 stacks of receiver...

BACKGROUND The hybrid zone between the primarily forest-dwelling American toad, Anaxyrus americanus, and the prairie-adapted Canadian toad, A. hemiophrys, in southeastern Manitoba is known to have shifted its position during the past 50 years. Hybrid zones are areas of interbreeding between species and their movement across a landscape should reflect their underlying dynamics and environmental ...

conclusions using tzpsad as an adjunct to psa may improve the specificity of psa in the diagnosis of pca and decrease the number of unnecessary prostatic biopsies in iranian men with serum psa level < 20 ng/ml. results among 1120 men who were eligible for enrolment, prostate cancer was detected in 265 patients. mean serum psa levels were 9.7 ± 4.3 ng/ml and 8.5 ± 3.7 ng/ml in patients with and ...

Through a detailed analysis of seismicity at the base of the transition zone, we obtain an updated value of the maximum reliable depth of confirmed seismicity, we investigate regional variation in the maximum depth of seismicity among those Wadati-Benioff zones which reach the bottom of the transition zone, and we attempt to quantify the maximum possible rate of seismic release in the lower man...

This article reviews previously described methods of fresh tissue sampling from radical prostatectomy specimens for research and describes a method used in Oxford which is simple, logical and cost effective. The method utilises a systematic zonal approach to tissue procurement in order to meet the increasing requirement for research samples with detailed morphological information such as zone o...

Refractive surgery is evolving rapidly. A recent development uses wavefront aberration information to improve the surgical outcome. Before the wavefront information can be used effectively a number of problems must first be resolved. One of the main concerns is the presence of halos during night driving conditions. It seems clear that this problem occurs when the pupil is large enough to overla...