A proportion of MYC translocation positive diffuse large B-cell lymphomas (DLBCL) harbour a BCL2 and/or BCL6 translocation, known as double-hit DLBCL, and are clinically aggressive. It is unknown whether there are other genetic abnormalities that cooperate with MYC translocation and form double-hit DLBCL, and whether there is a difference in clinical outcome between the double-hit DLBCL and tho...

SecA is a translocation ATPase that drives protein translocation. D209N SecA, a dominant-negative mutant, binds ATP but is unable to hydrolyze it. This mutant was inactive to proOmpA translocation. However, it generated a translocation intermediate of 18 kDa. Further addition of wild-type SecA caused its translocation into either mature OmpA or another intermediate of 28 kDa that can be translo...

Abstract Many countries have legislation intended to limit or offset the impact of anthropogenic disturbance and development on threatened plants. Translocations are often integral those mitigation policies. When translocation is used exclusively mitigate impacts, it termed a ‘mitigation translocation.’ However, both terminology processes vary regarding interpretation application, resulting in ...

Determination of the reinitiation time We define a single translocation event as the time from when the DNA end-to-end distance starts to decrease due to translocation activity until the point where the end-toend distance returns to its resting length due to termination of translocation. Considering only one of the translocation directions of a bidirectionally translocating enzyme, the reinitia...

Botulinum neurotoxins and tetanus are the strongest known toxins that cause neuroparalytic syndromes in botulism tetanus. This review aimed to systematize scientific data on structures mechanism of actions botulinum neurotoxins. proteins containing functional domains responsible for receptor binding, transmembrane translocation, proteolytic cleavage required exocytosis synaptic vesicles release...

MECHANISM OF TARGETING............................................................................................ 501 Signal Recognition Particle ...................................................................................... 502 Signal Sequences ............................................................. ............................. ..... ....... 507 SRP Receptor ............ . . .....

Abstract The population of the recently-described Whenua Hou diving petrel Pelecanoides whenuahouensis comprises c. 200 adults that all breed in a single 0.018 km 2 colony dune system vulnerable to erosion. species would therefore benefit from establishment second breeding through translocation. However, given small size source population, it is essential translocations are informed by carefull...

BACKGROUND/AIM Unlike animals, the incidence of bacterial translocation and its clinical significance remain to be determined in humans, which may be due to the lack of accurate methods to confirm and monitor bacterial translocation. The literature on the consequences of novel insights of bacterial translocation was reviewed. METHODS The Medline databases were searched for publications regard...