A clinico-morphological study of twelve patients of non-Hodgkin's lymphomas, diagnosed on bone marrow biopsy, is presented. They manifested with pyrexia of uncertain origin and/or unexplainable anaemia. These patients did not show any superficial lymphadenopa-thy, mediastinal lymph node enlargement or a specific mass in the abdomen. Eleven patients showed enlargement of the liver, whereas, elev...

Transilial bone samples were obtained at necropsy using trephine instruments with internal diameters of 2 mm and 7 mm. Undecalcified histological sections were prepared and two structural histomorphometric variables (percentage of trabecular bone volume and surface density of bone) were estimated by a Quantimet 720 image analyser. The differences between the variables measured from the two adja...

A case of IgD myeloma accompanied by diffuse osteosclerosis is reported. A trephine biopsy specimen showed only reticulin fibrosis, but histomorphometric analysis of a full thickness transiliac bone biopsy specimen showed increased trabecular bone mass, with no local deposit of tumour. An excess of bone surfaces were covered by osteoid seams, all of which showed active mineralisation, indicatin...

Disseminated tuberculosis is an important differential diagnosis for fever of unknown origin (FUO) and it can present with hepatosplenomegaly and lymphadenopathy and may have meningitis and with hematological abnormalities including pancytopenia or a leukemoid reaction. We report the case of a 13-year old male who presented with fever, weight loss, pallor and massive splenomegaly with pancytope...

Trephine biopsy was performed which showed hypercellular marrow space and several ill-defined granuloma lesions composed of histiocytes. Yeast-like organisms were seen stuffed within the histiocytes as well as in the interstitial space. Grocott and PAS stain revealed the presence of single, centrally located transverse septum in some of the organisms. These Date: 12 July, 2000 Venue: Yaumatei S...

Aim : This study aimed to clarify the ultrasound semiotics of colorectal cancer liver metastases contrast enhancement, and perform a comparative assessment diagnostic efficacy contrast-enhanced computed tomography (CT). Methods We studied 40 patients with cancer: receiving treatment for disease having newly diagnosed cancer. All underwent CT. In cases suspected malignancy, trephine biopsy morph...

The bone marrow examination is invaluable in the diagnosis of certain haematological and non haematological conditions. The diagnosis of haematological disorders is achieved mainly by the examination of peripheral blood and bone marrow aspirate smears. Although bone marrow histology can provide additional information, for many technical reasons, trephines are not so popular and their diagnostic...

A prospective study of bone marrow fibrosis was made in a group of 40 children with acute lymphoblastic leukaemia to see whether it affected the prognosis or course of the disease. Secondary myelofibrosis (SMF) was present at diagnosis in 57% of the cases. It was not statistically significantly related to the prognosis or course of the disease. Thus, although trephine biopsy occasionally provid...