The sequence of the nontranscribed spacer (NTS) region of the rDNA of Trichophyton mentagrophytes var. interdigitale strain 2111 was determined, and three individual subrepeat loci identified. The first repeat region contained eight tandem copies of a degenerate 33-43 bp sequence, whilst the second had two complete and two partial 300 bp repeats. The third locus contained six tandemly repetitiv...

BACKGROUND Transgenic research on metalloproteinase-1 is an emerging field in the area of plant molecular biology. The new method reported here can similarly be applied in fungal molecular biology to identify different dermatophytes. Our method is more accurate than traditional methods such as molecular analyses. OBJECTIVE To identify Trichophyton rubrum, T. mentagrophytes var. mentagrophytes...

BACKGROUND Tinea capitis affects mainly children. The frequency and causative organism vary from region to region. OBJECTIVES To provide epidemiological and mycological data on tinea capitis collected in urban and rural areas of the Dominican Republic. METHODS Samples were obtained from 118 patients with tinea capitis. Sixty-three of these were from 2 schools in urban areas of the Dominican...

Cassia alata Linn is an important medicinal plant as well as ornamental flowering plant. The leaf decoction of Cassia alata has been used to treat infectious diseases in north eastern Nigeria. This study was embarked upon so as to evaluate the safety and efficacy of Cassia alata in the management of fungal infectious diseases. The leaves of the plant were collected, dried and extracted using wa...

Onychomycosis is a common fungal nail infection in adults that is difficult to treat. The in vitro antifungal activity of efinaconazole, a novel triazole antifungal, was evaluated in recent clinical isolates of Trichophyton rubrum, Trichophyton mentagrophytes, and Candida albicans, common causative onychomycosis pathogens. In a comprehensive survey of 1,493 isolates, efinaconazole MICs against ...

INTRODUCTION In this study, we evaluated the chemical composition of a commercial sample of essential oil from Eucalyptus smithii R.T. Baker and its antifungal activity against Microsporum canis ATCC 32903, Microsporum gypseum ATCC 14683, Trichophyton mentagrophytes ATCC 9533, T. mentagrophytes ATCC 11480, T. mentagrophytes ATCC 11481, and Trichophyton rubrum CCT 5507. METHODS Morphological c...

The influence of undecylenic acid on the fungistatic effect of phenoxyethyldimethyldodecylammonium bromide (Domiphen bromide) against Trichophyton mentagrophytes was investigated. The unsaturated fatty acid was found to enhance the fungistatic activity of Domiphen bromide against this organism. The ratio of concentrations of these agents has a marked influence on the results of in vitro tests f...

Fagara zanthoxyloides was screened for biologically active ingredients and its antifungal activities. The results revealed that the plant extract possessed the following active ingredients: alkaloids, saponins, tannins and glycosides. The extract exerted inhibitory effect on Microsporum canis, Trichophyton rubrum and Trichophyton mentagrophytes. The minimum inhibitory concentration of the extra...

Around 90% of chronic dermatophyte infections are caused by the fungi Trichophyton mentagrophytes and Trichophyton rubrum. One of the causes of the chronic infection resides in the immunosuppressive effects of the cell-wall components of these organisms. Therefore we have attempted to identify the chemical structure of galactomannan, one of the major cell-wall components. The cell-wall polysacc...

Five mutants of Trichophyton mentagrophytes with changed optimum cultivation temperature and the wild strain were used in this study. The growth rates, the keratinolytic activities and the 1-D electrophoretic patterns of these mutants were examined repeatedly. The differences among the individual mutants and the wild strain can be useful for a better understanding of the participating individua...