نتایج جستجو برای: triclabendazole proteome
تعداد نتایج: 17375 فیلتر نتایج به سال:
With the available Arabidopsis genome and near-completion of the rice genome sequencing project, large-scale analysis of plant proteins with mass spectrometry has now become possible. Determining the proteome of a cell is a challenging task, which is complicated by proteome dynamics and complexity. The biochemical heterogeneity of proteins constrains the use of standardized analytical procedure...
Current SARS-CoV-2 vaccines take advantage of the viral spike protein required for infection in humans. Considering that proteins may contain both “self” and “nonself” sequences (sequences exist human proteome those do not, respectively), nonself are likely to be better candidate epitopes than self efficiently eliminate pathogenic reduce potential long-term risks autoimmune diseases. This viewp...
The Human Proteome Organization, or HUPO, was formed to promote research and large-scale analysis of the human proteome. By consolidating national proteome organizations into an international body, HUPO will coordinate international initiatives, biological resources, protocols, standards and data for studying the human proteome. HUPO has identified five key areas to advance study of the human p...
Fasciola hepatica (F. hepatica) as a foodborne trematode can occasionally cause hepatobiliary diseases. We report a 67-year-old woman who was referred to our center because of the diagnosis of cholangitis. She was a resident of mountainous area with the history of unsafe water and contaminated vegetables. Endoscopic retrograde cholangiopancreatography (ERCP) was performed as a diagnostic and th...
Abstract In higher plants, the xylem, which is crucial for water and nutrient transport, also contains a diverse proteome. The composition of xylem sap proteome responds dynamically to changes in environmental conditions. Important functions are maintenance structural integrity defense against invading pathogens. Knowledge on signals that trigger proteomic scarce. Better understanding these pro...
Finding the minimal set of gene functions needed to sustain life is of both fundamental and practical importance. Minimal gene lists have been proposed by using comparative genomics-based core proteome definitions. A definition of a core proteome that is supported by empirical data, is understood at the systems-level, and provides a basis for computing essential cell functions is lacking. Here,...
Control of Fasciola hepatica infection in livestock is based on annual treatment using flukicides such as triclabendazole, albendazole and closantel. However, triclabendazole resistant F. hepatica populations are emerging worldwide and resistance is emerging to albendazole, whereas it has until now never been described for closantel. In Sweden, a topical formulation containing a combination of ...
We present a stochastic model of proteolytic digestion of a proteome, assuming the distribution of parent protein lengths in the proteome, the relative abundances of the 20 amino acids in the proteome, and the digestion “rules” of the enzyme used in the digestion. We derived a closed form expression for the fragment mass distribution for a large class of enzymes including the widely used Trypsi...
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