Effects of the antimicrobial agent triclosan to natural periphyton communities (biofilms, comprising primarily microalgae and bacteria) were assessed in two independent experiments during spring and summer. For that purpose a semi-static test system was used in which periphyton was exposed to a concentration range of 5-9054 nmol/L triclosan. Effects on algae were analyzed as content and composi...

OBJECTIVE To compare the anti-plaque efficacy of a stabilized 0.454% stannous fluoride (referred to as SnF2) dentifrice versus a 0.3% triclosan dentifrice formulated with a copolymer and sodium fluoride (referred to as triclosan). METHODS The study had a randomized, double-blind, two-treatment, parallel-group design, and compared plaque reduction from baseline after both three and six weeks o...

Triclosan is a broad-spectrum antibacterial commonly used in cosmetics, dentifrices, and other consumer products. The compound's widespread use in consumer products and its detection in breast milk, urine, and serum have raised concerns regarding its potential association with various human health outcomes. Recent evidence suggests that triclosan may play a role in cancer development, perhaps t...

The crystalline bacterial biofilms that encrust Foley catheters compromise the care of many elderly and disabled patients. The aim of this study was to examine whether the biocide triclosan can prevent encrustation by the mixed flora of uropathogens that commonly infect patients undergoing long-term catheterization. Models of the catheterized bladder were inoculated with communities of organism...

Active efflux is regarded as a common mechanism for antibiotic and biocide resistance. However, the role of many drug efflux pumps in biocide resistance in Acinetobacter baumannii remains unknown. Using biocide-resistant A. baumannii clinical isolates, we investigated the incidence of 11 known/putative antimicrobial resistance efflux pump genes (adeB, adeG, adeJ, adeT1, adeT2, amvA, abeD, abeM,...

Subeffective exposure of Staphylococcus aureus to the biocide triclosan can reportedly induce a small-colony variant (SCV) phenotype. S. aureus SCVs are characterized by low growth rates, reduced pigmentation, and lowered antimicrobial susceptibility. While they may exhibit enhanced intracellular survival, there are conflicting reports regarding their pathogenicity. The current study reports th...

Triclosan has been incorporated into toothpaste to enhance inhibitory effects on bacterial metabolism in dental plaque. Many studies have confirmed these effects by showing a reduction of accumulation of dental plaque, gingivitis and calculus. However, there is no evidence for triclosan having an inhibitory effect on the dental plaque-induced demineralization of the dental hard tissues. Therefo...

BACKGROUND Peanut allergy is increasing in prevalence due to unknown factors. A growing body of clinical evidence suggests sensitization to peanut occurs through the skin, supported by findings in mouse models. There is a need to identify environmental factors that promote epicutaneous sensitization to peanut. Triclosan is an antimicrobial found in household products that has been associated wi...

One hundred forty pregnant women 3 months gestation were enrolled in a 9 month, double-blind clinical study to evaluate the effect of 0.3% triclosan/copolymer dentifrice on gingivitis, compared to a placebo dentifrice. Women were stratified into two balanced groups according to their baseline gingivitis scores. They then received oral prophylaxis and were assigned to use either a placebo or the...

In order to compare the antiplaque and antigingivitis activity of three commercially-available triclosan containing dentifrices with that of a placebo dentifrice without triclosan, a double-blind clinical study was conducted on 194 subjects over six months. Following baseline supragingival plaque and gingivitis examinations and a complete oral prophylaxis, subjects were stratified by their whol...