نتایج جستجو برای: trypanosoma
تعداد نتایج: 13673 فیلتر نتایج به سال:
The in-vitro activities of four anticancer alkyllysophospholipids, ET-18-OCH3 (edelfosine), hexadecylphosphocholine (miltefosine), ilmofosine and SRI 62-834, were determined with ED50 values for Leishmania donovani and Trypanosoma cruzi amastigotes between 0.2 and 5.0 microM and for Trypanosoma brucei trypomastigotes between 7.0 and 50.8 microM. In BALB/c mice miltefosine and ilmofosine were th...
Members of the protozoan order Kinetoplastida (Honigberg et al., 1964), which includes the genera Trypanosoma, Leishmania, and Crithidia, are characterized by the presence of a body known as a kinetoplast. The kinetoplast is a modified region of a mitochondrion (Meyer et al., 1958; Steinert, 1960; Clark and Wallace, 1960) which contains so much DNA that it can be detected by Feulgen staining (B...
Hemoparasitism is known to vary according the presence of vectors and hosts, hematological examination can be a useful tool for early diagnosis in avian medicine, contributing monitoring conservation bird populations. In this context, we aimed analyze clinical aspects free-ranging owls seized or rescued from Atlantic Forest biome Rio de Janeiro, Brazil. The animals, with without signs diseases,...
Trypanosoma cruzi and Trypanosoma rangeli are human-infective blood parasites, largely restricted to Central and South America. They also infect a wide range of wild and domestic mammals and are transmitted by a numerous species of triatomine bugs. There are significant overlaps in the host and geographical ranges of both species. The two species consist of a number of distinct phylogenetic lin...
A screen of a focused kinase inhibitor library against Trypanosoma brucei rhodesiense led to the identification of seven series, totaling 121 compounds, which showed >50 % inhibition at 5 μm. Screening of these hits in a T. b. brucei proliferation assay highlighted three compounds with a 1H-imidazo[4,5-b]pyrazin-2(3H)-one scaffold that showed sub-micromolar activity and excellent selectivity ag...
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In this work, we present the synthesis and anti-trypanosomal activity of 2-(4-(adamant-1-yl)phenyl)-N-hydroxyarylamides, 1a,b 2-(4-(adamant-1-yl)phenoxy)-N-hydroxyacetamide, 1c. The 4-(adamant-1-yl)phenyl- 4-(adamant-1-yl)phenoxy- moieties, which are endowed with promising drug-like properties, functionalized at side chain termini as hydroxamic acids. phenoxy acetohydroxamic derivative, 1c, sho...
The haptoglobin-haemoglobin receptor of the African trypanosome species, Trypanosoma brucei, is expressed when the parasite is in the bloodstream of the mammalian host, allowing it to acquire haem through the uptake of haptoglobin-haemoglobin complexes. Here we show that in Trypanosoma congolense this receptor is instead expressed in the epimastigote developmental stage that occurs in the tsets...
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