OBJECTIVE To evaluate the clinical profile of newborns with congenital hypothyroidism identified by the Newborn Screening Program of the State of Minas Gerais, Brazil, between 2000 and 2006. METHODS Analysis of factors involved in this profile, including: TSH and FT4 levels (determined by chemiluminescence, with limits of normality set at 0.3-5.0 microUI/mL and 0.8-1.8 ng/dL, respectively), a...

Routine treatment of thyroid cancer (TC) includes long-term suppression of TSH. The necessity of this treatment in low- and intermediate-risk patients as well as the extent of TSH suppression is currently under discussion. A literature search was performed to illustrate the role of TSH in extrathyroidal cells and to identify potential reasons for different effects of exogenously suppressed and ...

OBJECTIVE To use neonatal thyroid-stimulating hormone (TSH) concentration data to measure the iodine status of the population of the Australian state of Victoria. DESIGN, PARTICIPANTS AND SETTING Retrospective analysis of the results of 368,552 neonatal heel-prick blood tests for TSH concentration in Victoria in the years 2001-2006. MAIN OUTCOME MEASURES Iodine deficiency as indicated by a ...

most common congenital endocrine disease and avoidable cause of severe mental retardation. l-thyroxine supplementation started within 2–3 weeks of age can prevent severe neurological damage. Thus, neonatal screening programs have been instituted to allow early CH detection and initiation of therapy and still represent one of the major achievements of preventive medicine. The use of different st...

Introduction: To assess the relationship between parental consanguinity and permanent congenital hypothyroidism (PCH). Materials And Methods: From February 1998 to August 2002, cord dried blood spot samples, viz. only live births, in eight hospitals and a rural birth center in Tehran and Damavand were collected on Whatman BFC 180 filter papers. Samples with cord TSH  20 mU/L (two-site IRMA) ...

this study was aimed to evaluate the situation of congenital hypothyroidism (ch) in guilan using the screening program and determine the correlation of ch with birth weight, gestational age and seasonality. during 2006 to 2010, in guilan province, neonatal screening for ch by measurement of serum tsh level was performed in 3-5 days after birth. all neonates with tsh level ≥ 5mu/l were referred ...

riod. All showed increased TSH (43– 235 mIU/L). Four showed clearly decreased T4 [1.2–23.8 nmol/L (0.1– 1.85 g/dL)]. Another two had T4 concentrations below our cutoff of 30.8 nmol/L (2.4 g/dL), and only one had a T4 concentration within the reference interval [67 nmol/L (5.2 g/dL)]. This is in agreement with literature data that 10–20% of all CH cases with increased TSH concentrations are not ...

AIM The present large-scale Japanese population study was performed to evaluate the relation between the serum thyroid stimulating hormone (TSH) level and renal function. METHODS Out of 1,374 residents who participated in a free public physical examination between 2010 and 2011, we evaluated the data of 888 participants for whom the serum TSH level and estimated glomerular filtration rate (eG...