The authors describe an unusual presentation of lupus vulgaris in a 5-year-old boy. The lesions had a linear arrangement with proximal spread mimicking sporotrichosis. Histopathology of the lesions revealed tuberculoid granulomas. Tubercular etiology was confirmed by the demonstration of acid fast bacilli in the smears from the regional lymph node aspirate stained with Ziehl Neelsen stain, and ...

Infections are the commonest cause of morbidity and mortality in renal transplant recipients. In India, tuberculosis is a one such common infection in these patients and presents with protean manifestations. We report here a case of pyrexia of unknown origin (PUO) and segmental portal hypertension in a renal transplant recipient. Search for the cause of portal hypertension revealed abdominal tu...

Tubercular liver abscess is a rare extrapulmonary manifestation of tuberculosis. We are presenting a case of isolated tubercular liver abscess in a 70 year old diabetic male without any evidence of tuberculosis in the lungs or abdomen. Diagnosis was made on the basis of radiological findings along with PCR for Mycobacterium tuberculosis in pus aspirated from abscess under CT guidance. Systemic ...

Bilateral involvement of the breast with tuberculosis is extremely rare. It most commonly affects young lactating multiparous females, although rarely it may be reported in prepubescent males also. We present a case of a 27-year-old nulliparous female who presented with a history of multiple pus discharging sinuses around both areolae and was diagnosed as a case of bilateral tubercular mastitis...

Tubercular meningitis (TBM) can have varied early and delayed complications involving brain or spinal cord. Although syringomyelia can occur sometimes as a late complication of tubercular meningitis, its occurrence in early stages of TBM is very rare. There are only two published case reports of syringomyelia in acute stage of TBM. We report a patient with tubercular meningitis who developed sy...

Rectourethral fistula is an uncommon occurrence. The usual anatomic site of occurrence is the prostatic urethra,in which a communication develops with the rectum. The common causes are surgery or radiotherapy for prostate cancer. Inflammatory causes are rare, and amongst them, tuberculosis is even rarer. There are only 9 cases of tubercular rectourethral fistula reported in literature. In this ...

Prevalence to the various biological activities of imidazo[4,5-b] pyridine nucleus has promoted us for an attempt of one pot synthesis of (1H, 3H) imidazo [4,5-b] pyridines (desazopurines) as inhibitors of Lumazine synthase in M. tuberculosis (PDB 2C92). Major advantage of Lumazine synthase enzyme behind consideration as target protein in docking study is its absence in mammalian cell but prese...

Tubercular spinal epidural abscess (SEA) is is a devastating infectious disease. Its presence without associated osseous involvement may be considered an extremely rare scenario. We present a rare case of tubercular SEA complicated by paraplegia in an immune-competent 58-year-old male patient. MRI shows a multisegmental posterior collection of epidural fluid extending from C7 to L2 vertebral le...

A 9-year-old boy received a rifampicin-isoniazid-ethambutol regimen for suspected extra-pulmonary tuberculosis, and glucurolactone and vitamin B6 to provide liver protection and decrease neurotoxicity associated with isoniazid. Baseline serum aminotransferase and total bilirubin levels were within normal limits before anti-tubercular treatment. After 4 days of treatment, the patient's body temp...