During embryogenesis, blood vessels are formed initially by the process of vasculogenesis, the in situ differentiation of mesenchymal cells into endothelial cells, which form a primitive, patterned vasculogenic network. This is followed by angiogenesis, the sprouting of new vessels from preexisting vasculature, to yield a more refined microcirculation. However, we and our collaborators have rec...

AIM To compare the adhesion, migration and endothelial differentiation potential of peripheral blood-derived mononuclear cells (PBMCs) obtained from drug-naive normal glucose tolerance (NGT) and impaired glucose tolerance (IGT) Asian Indian men. METHODS Based on the 75-g oral glucose tolerance test, 30 NGT and 31 IGT subjects were recruited into the study. PBMCs were isolated from fasting blo...

Background & Aim: Colorectal carcinoma (CRC) is a leading cause of death in the world. It is 2nd most common cancer in Men & 3rd most common cancer in Women in the West. Colorectal carcinoma is more common in Developed countries. We have analyzed diagnostic role of colonoscopy in colorectal carcinoma. Methods: Patients admitted to General Surgery Department & Gastroenterology Department of SCB ...

Aim—To investigate factors that influence urinary tissue factor (uTF) measurements: glomerular permeability and filtration, tubular function, haematuria, and urine bacterial growth. Methods—uTF, protein creatinine index, glomerular filtration rate, retinol binding protein, N-acetyl-â-D-glucosaminidase (NAG) and urinary haemoglobin (uHb) were measured in patients with hypertension, diabetes mell...

distal renal tubular acidosis is a syndrome of abnormal urine acidification and is characterized by hyperchloremic metabolic acidosis, hypokalemia, hypercalciurea, nephrocalcinosis and nephrolithiasis. despite the presence of persistent hypokalemia, acute muscular paralysis is rarely encountered in males.here, we will report an eighteen year old male patient who presented with flaccid quadripar...

The key regulators of endothelial differentiation that is induced by shear stress are mostly unclear. Human atonal homolog 6 (Hath6 or ATOH8) is an endothelial-selective and shear-stress-responsive transcription factor. In this study, we sought to elucidate the role of Hath6 in the endothelial specification of embryonic stem cells. In a stepwise human embryonic stem cell to endothelial cell (hE...

Dear Editor-in-Chief, The inspissated meconium pellets are a cause or effect of ileocolic obstructions. The present study aimed at explaining our experience of ultrasound-based approach for differentiation and treatment of the inspissated meconium pellets. This study was conducted at Mashhad University of Medical Sciences, Mashhad, Iran, from 2017-2020...

Miniaturization of functional devices and systems demands new design and fabrication approaches for lab-on-a-chip application and optical integrative systems. By using a direct laser writing (DLW) technique based on two-photon polymerization (TPP), a highly integrative optofluidic refractometer is fabricated and demonstrated based on tubular optical microcavities coupled with waveguides. Such t...