نتایج جستجو برای: tumor associated macrophages
تعداد نتایج: 1906285 فیلتر نتایج به سال:
Macrophages are part of the tumor microenvironment and have been associated with poor prognosis in uveal melanoma. We determined the presence of macrophages and their differentiation status in a murine intraocular melanoma model. Inoculation of B16F10 cells into the anterior chamber of the eye resulted in rapid tumor outgrowth. Strikingly, in aged mice, tumor progression depended on the presenc...
Abstract IL1? is a central mediator of inflammation. Secretion typically requires proteolytic maturation by the inflammasome and formation membrane pores gasdermin D (GSDMD). Emerging evidence suggests an important role for in promoting cancer progression patients, but underlying mechanisms are ill-defined. Here, we have shown key driving tumor two distinct mouse models. Notably, activation inf...
Macrophages are key components of the innate immune system. The variability macrophage’s participation in tumor progression, determined by their functional polarization, opens up a wide prospect for modulating profile, primarily direction increasing antitumor activity. purpose study was to provide up-to-date data on process macrophage mechanisms its regulation, polarization markers and inductio...
Photodynamic therapy (PDT) is a promising method for skin pre-cancerous lesions and tumors. During PDT, photosensitizer (PS) activated by the appropriate wavelength of light in an oxygen environment to produce reactive species tumor-killing. Generally, photodynamic requires repeated treatment cycles, which can potentially induce resistance become increasing awareness clinical work. However, its...
Background . Prostate cancer (PCa) is the most common human worldwide. In progression of prostate cancer, total number macrophages in tumor tissue associated with poor prognosis and increased risk metastasis. However, heterogeneity intratumoral at various stages PCa development, role tumor-associated (TAMs) have been insuffciently investigated. The aim study was to analyze morphological feature...
Tumor-associated macrophages are key components of the tumor microenvironment and play important roles in progression head neck cancer, leading to development effective strategies targeting immune cells tumors. Our study demonstrated prognostic potential a new scoring system (Macroscore) based on combination ratio sum high low densities M1 (CD80+) M2 (CD163+) series cancer patients, including t...
Modulating the extracellular matrix microenvironment is critical for achieving desired macrophage phenotype in immune investigations or tumor therapy. Combining de novo protein design and biosynthesis techniques, herein, we designed a biomimetic polypeptide self-assembled nano-immunomodulator to trigger activation of specific phenotype. It was intended be made up (GGSGGPGGGPASAAANSASRAT...
Tumor-associated macrophages (TAMs) and tumor-associated neutrophils (TANs) can control cancer growth and exist in almost all solid neoplasms. The cells are known to descend from immature monocytic and granulocytic cells, respectively, which are produced in the bone marrow. However, the spleen is also a recently identified reservoir of monocytes, which can play a significant role in the inflamm...
Tumor associated macrophages (TAMs) are an important element of tumor stroma. They originate from blood monocytes attracted by chemokines and cytokines produced by tumor cells and, being instructed by tumor microenvironment, develop into potent tumor-supporting cell population. TAMs were demonstrated to directly stimulate tumor cell proliferation and to promote angiogenesis. Further TAMs provid...
In recent years, the influence of the tumor microenvironment (TME) on cancer progression has been better understood. Macrophages, one of the most important cell types in the TME, exist in different subtypes, each of which has a different function. While classically activated M1 macrophages are involved in inflammatory and malignant processes, activated M2 macrophages are more involved in the wo...
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